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Items: 1 to 20 of 55

1.

Inhibition of human CYP3A4

Source:
ChEMBL
Protein Target:
Cytochrome P450 3A4; 1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase; Taurochenodeoxycholate 6-alpha-hydroxylase
2.

Inhibition of human CYP2D6

Source:
ChEMBL
Protein Target:
Cytochrome P450 2D6; CYPIID6; Cholesterol 25-hydroxylase; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase
3.

Inhibition of human CYP2C19

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
4.

Inhibition of human CYP2C9

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C9; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC9; Cholesterol 25-hydroxylase; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase
5.

Inhibition of human CYP1A2

Source:
ChEMBL
Protein Target:
Cytochrome P450 1A2; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3
6.

Inhibition of FAS in mouse N42 cells assessed as [14C]-acetate incorporation after 4 hrs by scintillation counting

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
7.

Inhibition of human FAS assessed as synthesis of long chain fatty acids from malonyl CoA after 60 mins by fluorescence assay

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
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