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Results: 1 to 20 of 18290

1.

Inhibition of B-Raf activated MEK2 (unknown origin) assessed as ERK2-mediated MBP phosphorylation after 30 mins by ELISA [Confirmatory]

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
2.

Inhibition of MEK1/2 phosphorylation in human A375P cell lysate after 24 hrs by Western blotting analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
3.

Inhibition of MEK2 (unknown origin) at 30 uM

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
4.

Competitive binding affinity to MEK2 (unknown origin) at 10 uM in presence of ATP relative to control

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
5.

Inhibition of MAP2K2 in human PC3 cell lysates at 10 uM using desthiobiotin-tagged ATP probe AX9989 followed by trypsinization by LC/MS analysis

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
6.

Inhibition of MEK2 (unknown origin) at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
7.

Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
8.

Inhibition of MEK2 (unknown origin) assessed as remaining activity at 1 uM relative to control

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
9.

Inhibition of MEK2 (unknown origin) using [gamma-33P]ATP assessed as residual activity at 3 uM

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
10.

Inhibition of MEK2 (unknown origin) at 1 uM relative to control

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
11.

Inhibition of MEK2 (unknown origin) assessed as remaining activity at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
12.

Inhibition of recombinant MKK2 (unknown origin) assessed as residual activity using [gamma-33P]ATP as substrate at 1 uM

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
13.

Inhibition of MEK1/2 in human A549 cells coexpressing KRAS mutant assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
14.

Inhibition of MEk1/2 in human A375 cells assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
15.

Inhibition of MEk1/2 in human A549 cells assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
16.

Inhibition of MEk1/2 in human MCF7 cells assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
17.

Inhibition of MEk1/2 in human CCD-1070sk cells assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
18.

Inhibition of MEK2 (unknown origin) at 1 uM

Source:
ChEMBL
Protein Target:
Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
19.

Inhibition of MEK1/2 phosphorylation in human A549 cells after 24 hrs by Western blot analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2
20.

Inhibition of MEK1/2 in human LOX cells assessed as upregulation of p27 expression at 2 to 10 uM by Western blot analysis

Source:
ChEMBL
Protein Targets:
Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; ...
Total:
2

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