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Results: 1 to 20 of 149

1.

Inhibition of sEH (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
2.

Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
4.
5.

Ratio of AUDA IC50 to compound IC50 for recombinant human sEH

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
6.

Ratio of IK950 IC50 to compound IC50 for recombinant human sEH

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
7.

Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
8.

Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
9.
10.
11.

Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
12.
14.

Ratio of compound IC50 to sorafenib IC50 for human recombinant soluble epoxide hydrolase

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
15.
16.
18.

Inhibition of human recombinant soluble epoxide hydrolase

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
19.

Reversible inhibition of human recombinant soluble epoxide hydrolase assessed as residual enzyme activity at 10 uM after 15 mins relative to control

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
20.

Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrate [Confirmatory]

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase

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