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Items: 1 to 20 of 176

1.
2.

Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1194250
3.

Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
4.

Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
5.

Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1186229
6.

Inhibition of human recombinant soluble epoxide hydrolase assessed as conversion of 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid to fluorescent 6-methoxy-naphthaldehyde at 10 uM after 10 mins by fluorescence-based assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
7.

Ratio of IC50 for recombinant human soluble epoxide hydrolase in presence of 1 mg/mL BSA to IC50 for recombinant human soluble epoxide hydrolase in presence of 0.1 mg/mL BSA

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
8.

Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1139014
9.

Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1139013
10.

Displacement of ACPU from recombinant human soluble epoxide hydrolase after 1.5 hrs by FRET assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
11.

Displacement of ACPU from recombinant human soluble epoxide hydrolase assessed as compound residence time after 1.5 hrs by FRET assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
12.

Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
13.

Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
14.

Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
15.

Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1119537
16.

Inhibition of soluble epoxide hydrolase (unknown origin)

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1119535
17.

Inhibition of sEH (unknown origin)

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
18.

Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
19.

Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1064059
20.

Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
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