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hSERT and rVMAT2 Fluorometric Screening Assay from US Patent US20230382919: "OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS"
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
SERT Uptake Inhibition Assay from US Patent US11767305: "Advantageous benzofuran compositions for mental disorders or enhancement"
Assay data:13 Active, 11 Activity ≤ 1 µM, 13 Tested
Sert Binding Assay from US Patent US11576897: "Therapeutic agent for non-motor symptoms associated with Parkinson's disease"
Assay data:63 Active, 20 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 63 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Serotonin Transporter Binding Assay from US Patent US11555013: "Potent and selective inhibitors of monoamine transporters; method of making; and use thereof"
Assay data:27 Active, 13 Activity ≤ 1 µM, 52 Tested
Inhibition of serotonin transporter in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of serotonin transporter in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake at 1 uM relative to control
Assay data:18 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SERT (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to human SERT assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (CEREP ExpressProfile selectivity/specificity profile (human recombinant receptors)) EUB0000213bCl SLC6A4
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000328a SLC6A4
Selectivity interaction (Enzyme panel (CEREP ligand profiling)) EUB0000328a SLC6A4
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000753a SLC6A4
Selectivity interaction (Enzyme and Receptor panel (MSD Pharma/Taiwan)) EUB0000753a SLC6A4
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a SLC6A4
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000739a SLC6A4
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a SLC6A4
Binding affinity to SERT receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control
Inhibition of SERT receptor (unknown origin) at 10 uM relative to control
Inhibition of SERT (unknown origin) expressed in human HEK293 cells
Assay data:23 Active, 1 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 36 Tested
Inhibition of human SERT at 10 uM relative to control
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