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Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a ADAM17
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human ADAM17
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human TACE at 0.5 uM by fluorescence based assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TACE by fluorescence based assay
Inhibition of human TACE at 100 uM by fluorescence based assay
Peptidase, Tumor Necrosis Factor-alpha Converting Enzyme (TACE) Eurofins-Panlabs enzyme assay
Inhibition of human TACE at 100 uM relative to control
Assay data:5 Tested
In Vitro Assay from US Patent US10829478: "5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis"
Assay data:111 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
TR-FRET Assay from US Patent US10556883: "Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
hTACE assay from US Patent US10550100: "5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis"
Assay data:36 Active, 90 Activity ≤ 1 µM, 90 Tested
Cell-based Screening of Chemical Libraries for Characterization of Necroptosis Inhibitors from US Patent US10457678: "Substituted pyrrolo[2,3-b]pyridines as inhibitors of cellular necroptosis"
Assay data:10 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TACE Activity Assay from Article 10.3109/14756366.2011.599323: "Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-a converting enzyme (TACE/ADAM-17)."
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9365529: "Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
TACE Assay from Article 10.3109/14756366.2010.487485: "The evaluation of inhibitive effectiveness of the tumour necrosis factor-a converting enzyme selective inhibitors by HPLC."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
TACE Enzyme Assay from US Patent US9266848: "4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Enzyme Assay from US Patent US9115102: "N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Fluorescence Polarization Ligand Binding Assay from US Patent US8901310: "Tricyclic compounds, compositions, and methods"
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Enzymatic Assay from US Patent US8633196: "Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Enzyme Assay from Article 10.1074/jbc.M110.139634: "Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation."
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
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