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In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TNF-alpha RELEASE from US Patent US11365204: "Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors"
Assay data:67 Active, 71 Activity ≤ 1 µM, 71 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
TNF-alpha Secretion Assay from US Patent US11208399: "NLRP3 inflammasome inhibitors"
Assay data:107 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Comparison of the Effect of Corticosteroids, a ROCK Kinase and Compounds of the Invention on the Inhibition of ROCK-1 Kinase, ROCK-2 Kinase, and TNF-alpha from US Patent US11059789: "Isoquinoline-steroid conjugates and uses thereof"
TNF-alpha inducing NF-kappaB reporter from US Patent US10508103: "Benzimidazole-linked indole compound acting as novel divalent IAP antagonist"
Assay data:48 Active, 51 Activity ≤ 1 µM, 51 Tested
Cellular Necrosis Inhibition Activity from US Patent US10508102: "Inhibitors of cellular necrosis and related methods"
Assay data:9 Active, 8 Activity ≤ 1 µM, 11 Tested
Assay data:11 Active, 10 Activity ≤ 1 µM, 13 Tested
IRAK4 Monocyte TNFalpha Cell Based Assay from US Patent US10336762: "Pyrrolo[1,2-b]pyridazine derivatives"
Assay data:934 Active, 581 Activity ≤ 1 nM, 932 Activity ≤ 1 µM, 935 Tested
ELISA Assay from US Patent US9393245: "Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors"
Assay data:58 Active, 14 Activity ≤ 1 nM, 51 Activity ≤ 1 µM, 62 Tested
Surface Plasmon Resonance (SPR) Assay from Article 10.1074/jbc.M113.521708: "A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model."
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Biological Assay from US Patent US9120838: "Saccharide conjugates"
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition Assay from US Patent US8541572: "Compounds for the treatment of inflammatory disorders"
Assay data:288 Active, 245 Activity ≤ 1 nM, 286 Activity ≤ 1 µM, 289 Tested
TNF or CD40L-Induced HEK-Blue Assay from US Patent US10335392: "Cyclic compounds useful as modulators of TNF α"
Assay data:31 Active, 17 Activity ≤ 1 µM, 41 Tested
TNF induced HEK-Blue assay from US Patent US10308652: "Tricyclic heterocyclic compounds useful as inhibitors of TNF"
Assay data:54 Active, 15 Activity ≤ 1 µM, 60 Tested
AlphaLISA hTNFa kit from US Patent US10196374: "1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as SGRM modulators"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
TNF induced HEK-Blue assay from US Patent US10189840: "Substituted tricyclic heterocyclic compounds"
Assay data:40 Active, 28 Activity ≤ 1 µM, 40 Tested
Inhibition of LPS-induced TNFalpha in Human PBMCs from US Patent US10150755: "ASK1 inhibitor compounds and uses thereof"
Assay data:20 Active, 14 Activity ≤ 1 µM, 20 Tested
Enzymatic Inhibitory Assay from US Patent US9656996: "Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Assay data:14 Active, 20 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
TNF or CD40L-Induced HEK-Blue Assay from US Patent US10112944: "Heterocyclic compounds useful as inhibitors of TNF"
Assay data:37 Active, 27 Activity ≤ 1 µM, 37 Tested
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