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Results: 1 to 20 of 31097

1.

Displacement of [125I]SDF-1alpha from CXCR7 (unknown origin) expressed in CHO cells after 1 hr by TopCount scintillation counting analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
2.

Binding affinity to CXCR7 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
3.

Binding affinity to CXCR7 (unknown origin) at 10 uM by radioligand displacement assay

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
4.

Antagonist activity at CXCR7 (unknown origin) assessed as inhibition of calcium flux at 10 uM

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
5.

Antagonist activity at CXCR7 (unknown origin) assessed as inhibition of chemotaxis at 10 uM

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
6.

Agonist activity at human CXCR7 expressed in HEK293 cells assessed as reduction of receptor surface expression at 10'-5 M after 1 hr by ELISA based internalization assay

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
7.

Agonist activity at human CXCR7 expressed in HEK293 cells assessed as reduction of receptor surface expression after 1 hr by ELISA based internalization assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
8.

Agonist activity at human CXCR7 expressed in HEK293T cells co-expressing beta-arrestin2-YFP assessed as beta-arrestin2 recruitment after 1 hr by BRET assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
9.

Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrs [Confirmatory]

Source:
ChEMBL
Protein Target:
Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
10.

Affinity against human adrenomedullin receptor

Source:
ChEMBL
Protein Target:
G-protein coupled receptor 182
11.

Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assay [Confirmatory]

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; CD_antigen=CD182
12.

Displacement of [125I]GRO-alpha from human recombinant CXCR2 receptor expressed in CHO cells [Confirmatory]

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
13.

Antagonist activity at human recombinant CXCR2 receptor expressed in CHO cells assessed as inhibition of IL8-induced [35S]GTPgammaS binding by SPA method [Confirmatory]

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
14.

Inhibition of human CXCR2 at 10 uM relative to control

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
15.

Binding affinity to CXCR2 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
16.

Inhibition of CXCR2 (unknown origin) at 10 uM relative to control

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
17.

Inhibition of human CXCR2 receptor at 1 uM relative to control

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
18.

Binding affinity to human CXCR2 at 10 uM by radioligand displacement assay relative to control

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
19.

Displacement of [125I]-IL8 from human CXCR2 transfected in HEK293 cells after 4 hrs by microbeta counting analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182
20.

Antagonist activity at CXCR2 receptor (unknown origin) by [35S]GTPgammaS binding assay [Confirmatory]

Source:
ChEMBL
Protein Target:
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen=CD182

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