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Human Cytochrome P450 Inhibition Assay from US Patent US11834414: "1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use"
Assay data:5 Active, 15 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
qHTS for inhibitors of CYP3A4 against the NCATS DSHEA and TCM libraries
Assay data:330 Active, 10 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Against Cytochrome P450 Isoenzymes from US Patent US20230331739: "INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME"
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
CYP Enzyme (Cytocrome P450) Inhibition Assay from US Patent US20230303562: "PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:6 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
CYP3A4 Inhibitory Activity Assay from US Patent US11739089: "Acetamido-phenyltetrazole derivatives and methods of using the same"
Assay data:12 Active, 31 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Recombinant CYP Inhibition Assay from US Patent US11649235: "Pan-tropic entry inhibitors"
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of Cytochrome P450 Oxidase from US Patent US11643436: "Polypeptide compound, pharmaceutical composition, preparation method and application thereof"
Inhibition Assay from US Patent US11548860: "Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1"
Assay data:11 Active, 3 Activity ≤ 1 µM, 13 Tested
CYP Inhibition Assay from US Patent US11505526: "Aryl-piperidine derivatives"
Assay data:2 Active, 3 Tested
Metabolism dependent inhibition of CYP3A4 (unknown origin)
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP3A4 (unknown origin)
Inhibition of CYP450 (unknown origin)
Assay data:1 Tested
Inhibition of CYP3A4 in human liver microsomes using midazolam and testosterone as substrate in presence NADPH regenerating system
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Substrate activity at CYP3A4 (unknown origin)
Assay data:2 Active, 2 Tested
Inhibition of human hepatic CYP3A4 using midazolam as substrate measured after 3 mins by LC-MS analysis relative to control
Assay data:8 Tested
Inhibition of recombinant CYP3A4 (unknown origin) using midazolam as substrate assessed as reduction in substrate hydroxylation at 10 uM incubated for 5 mins in presence of NADPH by LC-MS/MS analysis relative to control
Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 5 mins followed by addition of NADPH measured after 5 mins by LC/MS/MS analysis relative to control
Inhibition of CYP3A4 in human liver microsomes at 0.01 to 30 uM using phenacetin as substrate in presence of NADPH by UPLC-MS/MS analysis
Assay data:3 Active, 6 Tested
Inhibition of CYP3A4 in human liver microsomes at 25 uM in the presence of NADPH
Inhibition of CYP3A4 (unknown origin) at 20 uM
Assay data:5 Tested
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