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Human death receptor 5 (Tumour necrosis factor (TNF) receptor family)
Assay data:2 Active, 2 Tested
SummaryRelated BioAssays by Target
Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay
Assay data:354 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay
Assay data:2127 Active, 2240 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Summary assay for small molecule Caspase-8 TRAIL sensitizers
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay
Assay data:3770 Active, 364168 Tested
Increase in DR5 promoter activity in SacI gene expressing human DLD1 cells at 17.5 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Increase in DR5 promoter activity in SacI gene expressing human DLD1 cells at 17.5 to 70 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of DR5 promoter activity in SacI gene expressing human DLD1 cells at 0.001 to 0.1 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:1 Tested
Induction of DR5 promoter activity in SacI gene expressing human DLD1 cells at 10 to 30 uM after 24 hrs by luciferase reporter gene assay relative to control
Assay data:3 Tested
Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 at 43.9 uM after 24 hrs by luciferase assay
Assay data:2 Tested
Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 at 39 uM after 24 hrs by luciferase assay
Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 cells at 18.5 uM after 24 hrs by luciferase assay
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