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Results: 1 to 20 of 19944

1.

Inhibition of B-Raf (unknown origin) at 100 nM

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
2.

Competitive binding to B-RAF kinase (unknown origin) at 100 nM to 100 uM after 60 to 120 mins by FRET analysis

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
3.

Binding affinity to B-RAF kinase (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
4.

Competitive binding affinity to B-RAF kinase (unknown origin) after 60 to 120 mins by FRET analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
5.

Inhibition of B-Raf (unknown origin) at 10 uM after 1 hr by HTRF method

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
6.

Inhibition of BRAF (unknown origin) at 1 uM relative to control

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
7.

Inhibition of B-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
8.

Inhibition of bRAF (unknown origin) at 1 uM

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
9.

Inhibition of B-Raf (unknown origin) after 1 hr by ADP-Glo assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
10.

Inhibition of BRAF (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
11.

Inhibition of N-terminal 6X-His tagged human wild-type BRAF by ELISA [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
12.

Ratio of sorafenib IC50 to compound IC50 for BRAF (unknown origin)

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
13.

Inhibition of BRAF (unknown origin)-mediated ERK phosphorylation [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
14.

Inhibition of B-Raf (unknown origin) at 1 uM

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
15.

Inhibition of BRAF (unknown origin) after 1 hr by LanthaScreen assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
16.

Ratio of sorafenib IC50 to compound IC50 for BRAF (unknown origin) after 1 hr by LanthaScreen assay

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
18.

Binding affinity to BRAF (unknown origin) assessed as equilibrium dissociation constant by surface plasmon resonance analysis

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
19.

Binding affinity to BRAF (unknown origin) assessed as dissociation half life by surface plasmon resonance analysis

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
20.

Inhibition of BRAF1 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1

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