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Results: 1 to 20 of 15740

1.

Competitive binding affinity to MAP4K1 (unknown origin) at 10 uM in presence of ATP relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
2.

Inhibition of human HPK1 in HL-60 cells lysate assessed as reduction of labeling of acyl-phosphate ATP probe at 100 nM

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
3.

Binding constant for HPK1 kinase domain [Confirmatory]

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
4.

Inhibition of human HPK1 in HL60 cells lysate at 10 uM using post probe-labeling by LC-MS/MS analysis relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
5.

Binding constant for MAP4K1 kinase domain [Confirmatory]

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
6.

Binding affinity to human HPK1 at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1
7.

Kinase inhibition selectivity assay for compound SID-48409448

Source:
Burnham Center for Chemical Genomics
Protein Targets:
3-phosphoinositide-dependent protein kinase 1 isoform 1 [Homo sapiens]; ...
Total:
314
8.

Kinase Inhibitor Selectivity Profiling Assay

Source:
Ambit Biosciences
Protein Targets:
3-phosphoinositide-dependent protein kinase 1 isoform 1 [Homo sapiens]; ...
Total:
287
9.

Competitive binding affinity to MAP4K5 (unknown origin) at 10 uM in presence of ATP relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
10.

Inhibition of MAP4K5 (unknown origin) at 50 times TAK1 Ki

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
11.

Inhibition of MAP4K5 (unknown origin) at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
12.

Inhibition of KHS1 (unknown origin) assessed as remaining activity at 1 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
13.

Inhibition of KHS1 (unknown origin) assessed as remaining activity at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
14.

Inhibition of human KHS1 in HL-60 cells lysate assessed as reduction of labeling of acyl-phosphate ATP probe at 100 nM

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
15.

Binding constant for MAP4K5 kinase domain [Confirmatory]

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
16.

Inhibition of human KHS1 in HL60 cells lysate at 10 uM using post probe-labeling by LC-MS/MS analysis relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
17.

Binding constant for MAP4K5 kinase domain [Confirmatory]

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
18.

Binding affinity to human KHS1 at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
19.

Binding affinity to human KHS1 [Confirmatory]

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
20.

Average Binding Constant for MAP4K5; NA=Not Active at 10 uM [Confirmatory]

Source:
ChEMBL
Protein Target:
Mitogen-activated protein kinase kinase kinase kinase 5; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5

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