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Items: 1 to 20 of 1100

1.

Selectivity ratio of IC50 for tonic block of human Nav1.7 to IC50 for blockade of inactivated state of human Nav1.7 by patch-clamp electrophysiology/cell based assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
2.

Selectivity ratio of IC50 for 10 Hz block of human Nav1.7 to IC50 for blockade of inactivated state of human Nav1.7 by patch-clamp electrophysiology/cell based assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
3.

Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
4.

Inhibition of human Nav1.7 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
5.

Inhibition of human Nav1.7 assessed as tonic block by patch-clamp electrophysiology/cell based assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
6.

Inhibition of Homo sapiens (human) NaV1.7 expressed in HEK293 cells assessed as decrease in [14C]guanidinium influx after 2 hr by liquid scintillation counting analysis

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
AID:
1113418
7.

Modulation of human Nav1.7 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiology

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
8.

Modulation of human Nav1.7 in closed state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiology

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
9.

Modulation of human Nav1.7 by automated patch clamp electrophysiology assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
10.

Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells by automated patch clamp assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
11.

Inhibition of human NaV1.7 channel expressed in HEK293 cells by FRET assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
12.

Binding affinity to inactivated state of human NaV1.7 channel assessed as inhibition of current evoked by 6 ms depolarizations to 0 mV from holding potential -70 mV at 3 uM by whole-cell patch clamp assay relative to vehicle-treated control

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
13.

Binding affinity to inactivated state of human NaV1.7 channel by whole-cell patch clamp assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
14.

Binding affinity to resting state of human NaV1.7 channel by whole-cell patch clamp assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
15.

Inhibition of NaV1.7 ion channel (unknown origin)

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
AID:
726420
16.

Inhibition of voltage-gated Na channel 1.7 (unknown origin)

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
17.

Binding affinity to human inactivated voltage-gated Na channel 1.7 expressed in HEK293 cells by patch-clamp technique

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
18.

Inhibition of human voltage-gated Na channel 1.7 expressed in HEK293 cells

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
19.

Inhibition of human voltage-gated Na channel 1.7 by cell based patch clamp technique

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
20.

Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay

Source:
ChEMBL
Protein Target:
Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7
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