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Items: 1 to 20 of 7078

1.

Activity of human recombinant CYP2C19 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 4-(2-(2,4-dimethylphenylthio)phenyl)piperazin-1-ol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
2.

Activity of human recombinant CYP2C19 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated compound formation treated with Lu AA21004 at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
3.

Activity of human recombinant CYP2C19 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated (3-methyl-4-(2-(piperazin-1-yl)phenylthio)phenyl)methanol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
4.

Activity of human recombinant CYP2C19 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
5.
6.

Activity of recombinant human CYP2C19 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with montelukast at 1 uM after 60 mins by LC-MS analysis

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
7.
8.

Drug level in human recombinant CYP2C19 expressed in insect cells coexpressing NADPH-P450 reductase measured per pmol of enzyme treated with 100 uM cinobufagin at 37 degC after 30 mins by UFLC-DAD-ESI-MS analysis

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
9.

Activity of human CYP2C19 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with [14C]-rivoglitazone at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
10.

Activity of human CYP2C19 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-((4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)methyl)-1-methyl-1H-benzo[d]imidazol-6-yl hydrogen sulfate formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
11.
12.
14.

Activity of human CYP2C19 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-amino-3-((1-carboxy-2-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)ethyl)disulfanyl)propanoic acid formation at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
16.

Activity of human CYP2C19 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with [14C]-rivoglitazone at 20 uM after 2 hrs by radio-HPLC/LC-MS/MS analysis in presence of NADPH-generating system and NADPH-generating system/SAM

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
17.
18.
20.
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