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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000730a CDKL3
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CDKL3 (unknown origin) assessed as fold change
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CDKL3 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
CDKL3 DiscoveRx kinase panel
CDKL3(h) Kinase panel
KinomeScan assay: inhibition of CDKL3
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
CDKL3(h) Eurofins Kinase panel
CDKL3(h) Millipore kinase panel
Inhibition of human CDKL3 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of CDKL3 (unknown origin) at 10 uM relative to control
Assay data:3 Tested
Inhibition of DNA-tagged human CDKL3 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human CDKL3 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of CDKL3 (unknown origin) by NanoBRET cellular target engagement assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of human partial length CDKL1 (M1 to D327 residues) expressed in bacterial system assessed as residual activity at 10 uM by kinome scan method relative to control
Inhibition of partial length human CDKL3 expressed in bacterial expression system assessed as activity remaining at 1 uM by kinome scan assay
Binding affinity to wild-type human partial length CDKL3 (M1 to D327 residues) expressed in bacterial expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control
Inhibition of wild-type human partial length CDKL3 (M1 to D327 residues) expressed in bacterial expression system at 1 uM by Kinomescan method relative to control
Inhibition of wild-type human partial length CDKL3 (M1 to D327 residues) expressed in bacterial expression system at 10 uM by Kinomescan method relative to control
Binding affinity to wild-type human partial length CDKL3 (M1 to D327 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
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