Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
In Vitro Assay for IDH1m (R132H or R132C) Inhibitors from US Patent US11667673: "Therapeutically active compounds and their methods of use"
Assay data:190 Active, 189 Activity ≤ 1 µM, 190 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical Assays for IDH1 and IDH2 Mutant Enzymes from US Patent US11649247: "7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Biochemical Assays for Wild-Type IDH1 and IDH2 Enzymes from US Patent US11629156: "7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical Assays for IDH1 and IDH2 Mutant Enzymes from US Patent US11629156: "7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Biochemical Assay from US Patent US11576906: "Inhibiting mutant IDH-1"
Assay data:19 Active, 1 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Enzymatic Assay from US Patent US11566013: "Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of IDH1 R132H mutant (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IDH2 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of IDH1 (unknown origin)
Assay data:2 Tested
Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 60 mins by Kinase-GLO reagent based assay
Assay data:23 Active, 22 Activity ≤ 1 µM, 25 Tested
In Vitro Biochemical Assay from US Patent US11376246: "Inhibiting mutant IDH-1"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
Cell Based Assays from US Patent US11311527: "Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)"
Enzyme Assay from US Patent US11203586: "Iridinesulfonamide compound and use method thereof"
Assay data:37 Active, 34 Activity ≤ 1 µM, 37 Tested
Enzyme Assay from US Patent US11111240: "Sultam compound and application method thereof"
Assay data:27 Active, 24 Activity ≤ 1 µM, 27 Tested
In Vitro Assays for IDH1m (R132H or R132C) Inhibitors from US Patent US11021515: "Therapeutically active compounds and their methods of use"
Assay data:189 Active, 188 Activity ≤ 1 µM, 189 Tested
Biochemical Assay from US Patent US11001596: "7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors"
In Vitro Assays for IDH2m R140Q Inhibitors from US Patent US10946023: "Therapeutically active compounds and their methods of use"
Assay data:31 Active, 32 Activity ≤ 1 µM, 32 Tested
In Vitro Assays for IDH1m (R132H or R132C) Inhibitors from US Patent US10946023: "Therapeutically active compounds and their methods of use"
Assay data:143 Active, 180 Activity ≤ 1 µM, 180 Tested
Assay data:250 Active, 255 Activity ≤ 1 µM, 255 Tested
Assay data:299 Active, 337 Activity ≤ 1 µM, 337 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on