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Results: 1 to 20 of 4574

1.

Inhibition of recombinant CYP2C19 (unknown origin) by LC/MS/MS analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
2.

Inhibition of CYP2C19 in human liver microsomes by LC-MS/MS/competitive screening assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
3.

Inhibition of CYP2C19 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
4.

Inhibition of CYP2C19 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
5.

Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin conversion to 4'-hydroxy mephenytoin preincubated for 10 mins followed by NADPH addition measured after 15 mins by LC-MS/MS analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
6.

Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin conversion to 4'-hydroxy mephenytoin at 0.25 uM preincubated for 10 mins followed by NADPH addition measured after 15 mins by LC-MS/MS analysis relative to control

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
7.

Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin conversion to 4'-hydroxy mephenytoin at 2.5 uM preincubated for 10 mins followed by NADPH addition measured after 15 mins by LC-MS/MS analysis relative to control

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
8.

Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin conversion to 4'-hydroxy mephenytoin at 25 uM preincubated for 10 mins followed by NADPH addition measured after 15 mins by LC-MS/MS analysis relative to control

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
9.

Inhibition of CYP2C19 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
10.

Inhibition of CYP2C19 in human liver microsomes after 2 to 45 mins by LC-MS/MS analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
11.

Inhibition of human CYP2C19 [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
12.

Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 15 mins by LC/MS/MS analysis [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
13.

Inhibition of CYP2C19 (unknown origin)

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
14.

Inhibition of CYP2C19 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
15.

Inhibition of CYP2C19 (unknown origin)

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
16.

Inhibition of CYP2C19 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
17.

Inhibition of recombinant CYP2C19 (unknown origin) using 7-ethoxy-3-cyanocoumarin as substrate [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
18.

Inhibition of recombinant CYP2C19 (unknown origin) using 7-ethoxy-3-cyanocoumarin as substrate at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
19.

Inhibition of CYP2C19 (unknown origin) [Confirmatory]

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
20.

Inhibition of CYP2C19 (unknown origin) at 1 to 200 uM

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase

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