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Results: 1 to 20 of 178

1.

Inhibition of FAS in mouse N42 cells assessed as [14C]-acetate incorporation after 4 hrs by scintillation counting [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
4.

Inhibition of rat FASN assessed as release of co-enzyme A [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
5.

Inhibition of FASN in rat NMU cells assessed as reduction of de novo synthesis of palmitate [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
6.

Inhibition of FASN in rat liver [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
7.

Inhibition of rat liver FAS at 60 uM by Coomassie blue staining

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
8.

Inhibition of rat liver FAS by Coomassie blue staining [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
9.

Inhibition of Sprague-Dawley rat liver fatty acid synthase at 60 umol

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
10.

Inhibition of Sprague-Dawley rat liver fatty acid synthase [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
11.

Decrease in fatty acid synthase activity in Wistar cafteria-fed rat epididymal adipose tissue at 70 mg/kg/day by DNA quantification assay

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
12.

Decrease in fatty acid synthase activity in lean Wistar rat epididymal adipose tissue assessed at 70 mg/kg/day by DNA quantification assay

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
13.

Decrease in fatty acid synthase activity in Wistar cafteria-fed rat inguinal adipose tissue at 70 mg/kg/day by DNA quantification assay

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
14.

Decrease in fatty acid synthase activity in lean Wistar rat inguinal adipose tissue assessed at 70 mg/kg/day by DNA quantification assay

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
15.

Inhibition of rat FAS [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
16.

Fatty acid synthase inhibitor

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
17.

Inhibition of human FASN assessed as release of co-enzyme A [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
18.

Inhibition of FASN in human HeLa cells assessed as reduction of de novo synthesis of palmitate [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
19.

Inhibition of FASN binding to FP-biotin in [12C][14N]-lysine, arginine and [13C6][15N2]-lysine, arginine labeled HEK293T cells at 20 uM after 1 hr by isotopic activity-based protein profiling-MudPIT assay

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase
20.

Inhibition of FASN in human HepG2 cells [Confirmatory]

Source:
ChEMBL
Protein Target:
Fatty acid synthase; Includes: [Acyl-carrier-protein] S-acetyltransferase; Includes: [Acyl-carrier-protein] S-malonyltransferase; Includes: 3-oxoacyl-[acyl-carrier-protein] synthase; Includes: 3-oxoacyl-[acyl-carrier-protein] reductase; Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: Enoyl-[acyl-carrier-protein] reductase; Includes: Oleoyl-[acyl-carrier-protein] hydrolase

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