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Results: 1 to 20 of 7131

1.

Summary of probe development efforts to identify activators of the Retinoic Acid Receptor-related orphan receptor A (RORA). [Summary]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
2.

Summary of probe development efforts to identify inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA). [Summary]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
3.

Dose-response cell-based assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [Confirmatory]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
4.

Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [Confirmatory]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
5.

Dose-response cell-based assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [Confirmatory]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
6.

Counterscreen for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [Confirmatory]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
7.

Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [Primary Screening]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
8.

Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [Primary Screening]

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha
9.

Inverse agonist activity at human RORalpha expressed in HEK293 cells at 1 uM after 18 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
10.

Inverse agonist activity at human RORalpha expressed in HEK293 cells at 10 uM after 18 hrs by luciferase reporter gene assay

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
11.

Inverse agonist activity at human RORalpha expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
12.

Inverse agonist activity at GAL4-fused human RORa expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
13.

Partial agonist activity at GST-fussed RORalpha (unknown origin) assessed as recruitment of TIF2-BAP protein after overnight incubation by pull down assay relative to 7DC

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
14.

Partial agonist activity at GST-fussed RORalpha (unknown origin) assessed as recruitment of TIF2-BAP protein after overnight incubation by pull down assay [Confirmatory]

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
15.

Partial agonist activity at GST-fussed RORalpha (unknown origin) assessed as recruitment of TIF2-BAP protein at 30 uM after overnight incubation by pull down assay relative to 7DC

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
16.

Partial agonist activity at GST-fussed RORalpha (unknown origin) assessed as recruitment of TIF2 mutant-BAP protein after overnight incubation by pull down assay

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
17.

Antagonist activity at transactivation domain of RORalpha (unknown origin) expressed in Drosophila Schneider cells co-expressing Gal4-DNA binding domain up to 96 uM

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
18.

Antagonist activity RORalpha in human Th17 cells assessed as inhibition of cell differentiation by measuring IL-17A expression at 0.5 uM after 6 days by flow cytometry

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha
19.

Modulation of ROR-alpha (unknown origin)

Source:
ChEMBL
Protein Target:
Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha

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