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Results: 1 to 20 of 166

1.

Inhibition of human recombinant soluble epoxide hydrolase assessed as conversion of 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid to fluorescent 6-methoxy-naphthaldehyde at 10 uM after 10 mins by fluorescence-based assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
2.

Ratio of IC50 for recombinant human soluble epoxide hydrolase in presence of 1 mg/mL BSA to IC50 for recombinant human soluble epoxide hydrolase in presence of 0.1 mg/mL BSA

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
3.

Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1139014
4.

Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1139013
5.

Displacement of ACPU from recombinant human soluble epoxide hydrolase after 1.5 hrs by FRET assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
6.

Displacement of ACPU from recombinant human soluble epoxide hydrolase assessed as compound residence time after 1.5 hrs by FRET assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
7.

Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
8.

Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
9.

Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
10.

Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1119537
11.

Inhibition of soluble epoxide hydrolase (unknown origin)

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1119535
12.

Inhibition of sEH (unknown origin)

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
13.

Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
14.

Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
AID:
1064059
15.

Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
16.

Ratio of AUDA IC50 to compound IC50 for recombinant human sEH

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
17.

Ratio of IK950 IC50 to compound IC50 for recombinant human sEH

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
18.

Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
19.

Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay

Source:
ChEMBL
Protein Target:
Bifunctional epoxide hydrolase 2; Includes: Cytosolic epoxide hydrolase 2; CEH; Epoxide hydratase; Soluble epoxide hydrolase; SEH; Includes: Lipid-phosphate phosphatase
20.

Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB

Source:
Shanghai Institute of Organic Chemistry
Protein Targets:
Chain 1, Crystal Structure Of Gamma-Chymotrypsin In Complex With 7- Hydroxycoumarin; ...
Total:
3277
AID:
977608

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