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Binding affinity to TXRD1 in human NCI-H522 cells at 10 uM incubated for 1 hr by Biotin-TAMRA pull down based mass spectrometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to TXRD1 in human NCI-H522 cells at 10 uM incubated for 1 hr by Biotin-TAMRA pull down based western blot analysis
Inhibition of Recombinant TrxR1 and GR from US Patent US11208384: "Sulfinylpyridines and their use in the treatment of cancer"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US11168069: "Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of Recombinant TrxR1 from US Patent US11161815: "Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:33 Active, 32 Activity ≤ 1 µM, 33 Tested
Inhibition Assay from US Patent US11028067: "Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
In vitro Assay from US Patent US9018255: "Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system"
Assay data:6 Active, 7 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to rat TrxR1 assessed as adduct formation at 7.2 uM by LC-MS/MS analysis
Inhibition of TrxR1 in human U87-TxR cells assessed as increase in RONS level at 10 uM measured after 24 hrs by dihydrorhodamine 123 dye based flow cytometry
Assay data:7 Active, 7 Tested
Inhibition of TrxR1 in human U87 cells assessed as increase in RONS level at 10 uM measured after 24 hrs by dihydrorhodamine 123 dye based flow cytometry
Assay data:5 Active, 5 Tested
Inhibition of recombinant rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by colorimetry
Assay data:7 Active, 3 Activity ≤ 1 µM, 8 Tested
Potency index, ratio of piperlongumine IC50 to test compound IC50 for inhibition of TrXr in human BEL-7402/5-FU cells
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TrxR in human BEL-7402/5-FU cells by colorimetric assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of thioredoxin reductase in human A549/CDDP cells by DTNB dye based microplate spectrophotometry
Assay data:5 Active, 7 Tested
Inhibition of thioredoxin reductase in human A549 cells by DTNB dye based microplate spectrophotometry
Inhibition of thioredoxin reductase (unknown origin) after 2 hrs by DTNB dye based microplate spectrophotometry
Reversible inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins in presence of NADPH followed by substrate addition and measured for 20 mins by Ellman's method
Assay data:6 Active, 6 Tested
Inhibition of TrxR1 (unknown origin) using DTNB as substrate preincubated for 30 mins in presence of insulin followed by substrate addition by colorimetry
Assay data:6 Active, 3 Activity ≤ 1 µM, 14 Tested
Inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
Assay data:6 Active, 2 Activity ≤ 1 µM, 14 Tested
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