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Fluorescence Polarization Assay from US Patent US11542290: "Phenothiazine derivatives and uses thereof"
Assay data:30 Active, 5 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescence spectroscopy from Article 10.1016/j.chembiol.2004.11.007: "Enhanced ligand affinity for receptors in which components of the binding site are independently mobile."
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to CALM2 in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H] ifenprodil from bovine CaM-agarose incubated for 30 mins by liquid scintillation spectrometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CaM (unknown origin) by equilibrium dialysis method
Assay data:1 Active, 3 Tested
Displacement of [3H]trifluoperazine from bovine brain CaM in presence of calcium
Binding affinity to CaM (unknown origin) by isothermal titration calorimetric analysis in presence of calcium2+
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to dansylated bovine testes CaM by fluorescence analysis in presence of calcium2+
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Binding affinity to bovine brain CaM by FTPFACE analysis
Assay data:7 Active, 1 Activity ≤ 1 µM, 10 Tested
Competitive binding affinity to human recombinant CaM by Cy5 dye labeled W-7-based fluorescence polarization analysis
Displacement of [3H]W-7 from bovine brain CaM
Binding affinity to dansylated bovine brain CaM assessed as half maximal increase in fluorescence by fluorescence analysis
Assay data:3 Active, 3 Tested
Binding affinity to human calmodulin by isothermal titration calorimetry
Assay data:4 Tested
Inhibition of human CaM/Src kinase SH2 domain interaction assessed as apparent association of CaM-Src kinase SH2 domain at 25 fold excess compound concentration by isothermal titration calorimetry
Inhibition of human CaM/Src kinase SH2 domain interaction assessed as apparent association of CaM-Src kinase SH2 domain at 10 fold excess compound concentration by isothermal titration calorimetry
Binding affinity to recombinant human calmodulin assessed as inhibition of calcineurin phosphatase activity using R2 phosphopeptide substrate at 3 to 10 uM after 30 mins by malachite green staining-based colorimetric analysis in presence of CaCl2
Binding affinity to Ca2+/calmodulin complex in preosteoclast derived from ICR mouse bone marrow-derived macrophages assessed as inhibition of NFATc1 nuclear translocation at 0.3 to 10 uM preincubated for 30 mins with M-CSF followed by RANKL induction measured after 30 mins by Western blot analysis
Binding affinity to Ca2+/calmodulin complex in preosteoclast derived from ICR mouse bone marrow-derived macrophages assessed as inhibition of CREB phosphorylation at S133 preincubated for 30 mins with M-CSF followed by RANKL induction measured after 30 mins by Western blot analysis
Binding affinity to Ca2+/calmodulin complex in preosteoclast derived from ICR mouse bone marrow-derived macrophages assessed as inhibition of CaMK-4 phosphorylation at T196 preincubated for 30 mins with M-CSF followed by RANKL induction measured after 30 mins by Western blot analysis
Binding affinity to bovine brain calmodulin at 0.1 mM after 60 mins by gel mobility shift assay in presence of EGTA
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