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Results: 1 to 20 of 370

1.

Thioredoxin reductase 1 inhibitor

Source:
ChEMBL
Protein Target:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
2.

Inhibition of human recombinant TrxR1 at pH 7.4 [Confirmatory]

Source:
ChEMBL
Protein Target:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
3.

Ratio of kcat to Km for human recombinant TrxR1 at pH 7.4

Source:
ChEMBL
Protein Target:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
4.

Activity at human recombinant TrxR1 at pH 7.4 [Confirmatory]

Source:
ChEMBL
Protein Target:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
5.

Inhibition of TrxR1 in human MCF7 cell lysates at 5.0 uM by insulin assay

Source:
ChEMBL
Protein Target:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
6.

Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 100 uM

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
7.

Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 50 uM

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
8.

Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 25 uM

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
9.

Inhibition of human thioredoxin signalling assessed as inhibition of insulin reduction at 10 uM

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
10.

Inhibition of human TrxR [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
11.

Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (1.3 uM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 100 uM NADPH; Not determined

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
12.

Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (100 nM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH; Not determined

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
13.

Inhibitory concentration against wild type human thioredoxin reductase (30 nM) pre-incubated for 10 min at 25 degree C in phosphate buffer in the presence of 100 uM NADPH; Not determined

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
14.

Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (1.3 uM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 100 uM NADPH [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
15.

Inhibitory concentration against wild type mutant human thioredoxin reductase (Sec498Cys) (100 nM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
16.

Inhibitory concentration against wild type mutant human thioredoxin reductase (hTrxRdelta-16) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
18.

Inhibitory concentration against wild type human thioredoxin reductase (5 nM) pre-incubated for 10 min at 25 degree C in buffer in the presence of 200 uM NADPH [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
19.

Inhibitory concentration (25 uM) against human thioredoxin reductase [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3
20.

Inhibitory concentration against human thioredoxin reductase [Confirmatory]

Source:
ChEMBL
Protein Targets:
Thioredoxin reductase 1, cytoplasmic; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1; ...
Total:
3

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