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Items: 1 to 20 of 18123

1.

Inhibition of FLT3 D835Y mutant (unknown origin) at 0.1 uM

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
2.

Inhibition of FLT3 (unknown origin) at 0.1 uM

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
3.

Inhibition of FLT3 (unknown origin) at 100 nM

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
4.

Binding affinity to human FLT3

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
5.

Binding affinity to human FLT3 at 10 uM relative to control

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
6.

Inhibition of FLT3 (unknown origin) at 10 uM after 30 mins by HTRF method

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
7.

Inhibition of FLT3 (unknown origin) assessed as reduction in kinase activity at 10 uM using ATP

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
8.

Decrease in FLT3 phosphorylation in human HEL cells at 0.1 to 0.5 uM after 24 hrs by Western blot analysis

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
9.

Inhibition of human recombinant FLT3 after 1 hr by LanthaScreen assay platform

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
10.

Inhibition of FLT3 ITD mutant in human MV4-11 cells assessed as cell growth inhibition after 48 hrs by CellTiter-Glo assay

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
11.

Inhibition of FLT3 ITD mutant in human MOLM14 cells assessed as cell growth inhibition after 48 hrs by CellTiter-Glo assay

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
12.

Inhibition of FLT3 ITD F691L mutant (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 48 hrs by CellTiter-Glo assay

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
13.

Inhibition of FLT3 ITD D835V mutant (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 48 hrs by CellTiter-Glo assay

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
14.

Inhibition of FLT3 ITD mutant (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 48 hrs by CellTiter-Glo assay

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
15.

Inhibition of FLT3 (unknown origin) using FAM-EPLYWSFPA as substrate preincubated for 60 mins followed by substrate addition by microfluidics assay in presence of 190 uM ATP

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
16.

Inhibition of FLT3 (unknown origin) using FAM-EPLYWSFPA as substrate at 20 uM preincubated for 60 mins followed by substrate addition by microfluidics assay in presence of 190 uM ATP relative to control

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
17.

Inhibition of human LRRK2 using RLGRDKYKTLRQIRQ substrate, ATP and [gamma33P]ATP at 1 uM

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
18.

Inhibition of human FLT3 using EAIYAAPFAKKK substrate, ATP and [gamma33P]ATP at 1 uM

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
19.

Inhibition of FLT3 (unknown origin)

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
20.

Inhibition of FLT3 (unknown origin)

Source:
ChEMBL
Protein Target:
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen=CD135
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