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Agonist activity at RXRbeta-LBD (unknown origin) assessed as transactivation by measuring increase in fluorescein-labelled coactivator D22 peptide recruitment by Lanthascreen TR-FRET assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at RXRalpha-LBD (unknown origin) assessed as transactivation by measuring increase in fluorescein-labelled coactivator PGC-1alpha peptide recruitment by Lanthascreen TR-FRET
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at RXRalpha-LBD (unknown origin) assessed as transactivation by measuring increase in fluorescein-labelled coactivator PGC-1alpha peptide recruitment at 60 uM by Lanthascreen TR-FRET assay relative to control
Assay data:1 Tested
Displacement of CBTF-BODIPY from RXR-alpha LBD (unknown origin) at 0.03125 to 32 uM incubated for 1 hr by fluorescence polarization assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human RXRalpha LBD (T225 to T462 residues) assessed as gibbs free energy change by isothermal titration calorimetry
Assay data:4 Tested
Binding affinity to human RXRalpha LBD (T225 to T462 residues) assessed as change in entropy by isothermal titration calorimetry
Binding affinity to human RXRalpha LBD (T225 to T462 residues) assessed as change in enthalpy by isothermal titration calorimetry
Binding affinity to human RXRalpha LBD (T225 to T462 residues) assessed as binding constant by isothermal titration calorimetry
Assay data:4 Active, 4 Tested
Agonist activity at human GAL4-fused RXRalpha LBD (T225 to T462 residues) expressed in HEK293 cells incubated for 24 hrs by Dual-Glo luciferase assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Binding affinity to human RXRalpha LBD (T225 to T462 residues) by fluorescence quenching assay
Agonist activity at human RXR-beta expressed in U2OS cells by PathHunter assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human RXR-alpha expressed in U2OS cells by PathHunter assay
Agonist activity at human RXR-beta expressed in U2OS cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to 9-cis-retinoic acid
Agonist activity at human RXR-alpha expressed in U2OS cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to 9-cis-retinoic acid
Agonist activity at RXRalpha (unknown origin) using fluorescein-D22 as substrate by fluorescence polarization assay relative to control
Agonist activity at RXRalpha (unknown origin) using fluorescein-D22 as substrate by fluorescence polarization assay
Agonist activity at human RXRbeta (294 to 533 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human RXRgamma (229 to 463) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human RXRalpha (225 to 462 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Agonist activity at human RXR-alpha expressed in African green monkey COS-1 cells assessed as NEt-TMN-induced receptor transactivation by luciferase reporter gene assay
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