Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19200991.

p38 Inhibitory Potency Assay from US Patent US11844801: "Oral compositions of MK2 pathway inhibitor for treatment of immune conditions"

Source:: BindingDB

Protein Targets:: MAP kinase-activated protein kinase 5; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1920099

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19195902.

ERK2 Enzymatic Assay from US Patent US11708364: "Azaindole derivatives and their use as ERK kinase inhibitors"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase 1; ...
Total:: 1

Assay data:90 Active, 92 Activity ≤ 1 µM, 92 Tested

AID:: 1919590

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19195213.

Biochemical Assay (10 uM) from US Patent US11685719: "Pyridinone MK2 inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: Mitogen-activated protein kinase 1; ...
Total:: 2

Assay data:23 Active, 5 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested

AID:: 1919521

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19195204.

Biochemical Assay (1 uM) from US Patent US11685719: "Pyridinone MK2 inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: MAP kinase-activated protein kinase 5; ...
Total:: 3

Assay data:23 Active, 2 Activity ≤ 1 µM, 24 Tested

AID:: 1919520

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19150325.

Selectivity interaction (Leadprofiling screen (Ricerca, enzymes, receptors, transporters, and ion channels )) EUB0000347a MAPK3

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 3

Assay data:1 Tested

AID:: 1915032

Summary Related BioAssays by Target

Select item 19149126.

Selectivity interaction (MSD Pharma/Taiwan screen (enzymes and receptors) ) EUB0000296b MAPK3

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 3

Assay data:1 Tested

AID:: 1914912

Summary Related BioAssays by Target

Select item 19141737.

Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1914173

Summary Related BioAssays by Target

Select item 19134068.

Selectivity interaction (Enzymatic assay) EUB0000609a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Tested

AID:: 1913406

Summary Compounds, Active Related BioAssays by Target

Select item 19134059.

Selectivity interaction (Ambit kinase binding assay panel) EUB0000609a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1913405

Summary Related BioAssays by Target

Select item 191321610.

Affinity Biochemical interaction (KdELECT (DiscoverX)) EUB0000298b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913216

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191321511.

Affinity Biochemical interaction (KdELECT (DiscoverX)) EUB0000298b MAPK3

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913215

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191316212.

Affinity Biochemical interaction (Enzymatic assay) EUB0000700a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Tested

AID:: 1913162

Summary Compounds, Active Related BioAssays by Target

Select item 191295813.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000298b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912958

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191295714.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000298b MAPK3

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 3

Assay data:1 Active, 1 Tested

AID:: 1912957

Summary Compounds, Active Related BioAssays by Target

Select item 191290415.

Affinity On-target Cellular interaction (Cellular assay (inhibition of RSK phosphorylation, A375SM cells)) EUB0000700a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1912904

Summary Related BioAssays by Target

Select item 191277316.

Affinity Phenotypic Cellular interaction (Anti-proliferation assay (A375SM cells)) EUB0000298b MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912773

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191277217.

Affinity Phenotypic Cellular interaction (Anti-proliferation assay (A375SM cells)) EUB0000298b MAPK3

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912772

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191274618.

Affinity Phenotypic Cellular interaction (Anti-proliferation assay (A375SM cells)) EUB0000700a MAPK1

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1912746

Summary Related BioAssays by Target

Select item 191274519.

Affinity Phenotypic Cellular interaction (Anti-proliferation assay (A375SM cells)) EUB0000700a MAPK3

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 3

Assay data:1 Tested

AID:: 1912745

Summary Related BioAssays by Target

Select item 191256020.

Thermal Shift Assay. Domain: start/stop: M1-S360

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:27 Tested

AID:: 1912560

Summary Related BioAssays by Target

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Proteins (25)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (492)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (75)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (246)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (499)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (17)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (1,587)
BioAssays extracted from the literature
NIH MLP (18)
BioAssays deposited by the NIH Molecular Libraries Program
Other (1,042)
BioAssays deposited by other experimentalists

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