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Enzyme (COXs) Inhibition Assay from US Patent US11786535: "Methods of inhibiting cyclooxygenase"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of COX2 (unknown origin) assessed as reduction in PGF2alpha content using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Selectivity interaction (CEREP Wide Ligand screening panel (ion channels, receptors, enzymes)) EUB0000304b PTGS2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (NIBR principial panel (12 GPCRs, 3 nuclear receptors, 3 transporters, and 7 other enzymes)) EUB0000254b PTGS2
Selectivity interaction (Enzyme panel (Eurofins-Cerep)) EUB0000262b PTGS2
Selectivity interaction (CEREP panel (Eurofins, binding assay)) EUB0000262b PTGS2
Inhibition of human COX2
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry
Assay data:3 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of full-length ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry
Assay data:2 Active, 1 Activity ≤ 1 µM, 10 Tested
Inhibition of human COX-2 at 50 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control
Assay data:24 Tested
Inhibition of human COX-2 at 5 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control
Inhibition of full-length ovine COX-1 at 50 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control
Inhibition of full-length ovine COX-1 at 5 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control
Inhibition of COX-2 in human NALM-6 cells assessed as downregulation of COX-2 expression by measuring COX-2 expression at 10 to 30 uM incubated for 48 hrs by DAPI staining based immunofluorescence based analysis relative to control
Inhibition of COX2 (unknown origin)
Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Binding affinity to COX2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human COX1
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of COX2 in human whole blood measured after 30 mins by radioimmunoassay
Assay data:2 Active, 2 Tested
Inhibition of COX1 (unknown origin)
Assay data:9 Active, 3 Activity ≤ 1 µM, 13 Tested
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