BioAssay by Target (List) for Gene (Select 775) - PubChem BioAssay - NCBI

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Select item 19151911.

Selectivity interaction (Eurofins Panlabs panel (receptors, ion channel, and other enzymes)) EUB0000310b CACNA1C

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1915191

Summary Related BioAssays by Target

Select item 19120882.

Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells assessed as Ca2+ current at -80 mV holding potential by patch clamp technique

Source:: ChEMBL

Protein Targets:: Voltage-dependent L-type calcium channel subunit alpha-1C; ...
Total:: 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1912088

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19076053.

Inhibition of human Cav1.2 at 10 uM relative to control by Electrophysiological QPatch assay

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1907605

Summary PubMed Citation Related BioAssays by Target

Select item 18981394.

Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells assessed as effect on calcium flux by FLIPR analysis

Source:: ChEMBL

Protein Targets:: Voltage-dependent L-type calcium channel subunit alpha-1C; ...
Total:: 3

Assay data:1 Tested

AID:: 1898139

Summary PubMed Citation Related BioAssays by Target

Select item 18976345.

Inhibition of human CaV1.2 at 10 uM relative to control

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1897634

Summary PubMed Citation Related BioAssays by Target

Select item 18810646.

Inhibition of CaV1.2 (unknown origin) by patch clamp method

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1881064

Summary PubMed Citation Related BioAssays by Target

Select item 18810177.

Inhibition of Cav1.2 (unknown origin) at 10 uM

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1881017

Summary PubMed Citation Related BioAssays by Target

Select item 18775888.

Inhibition of CAV1.2 (unknown origin)

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Active, 1 Tested

AID:: 1877588

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18758089.

Inhibition of Cav1.2 (unknown origin)

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1875808

Summary PubMed Citation Related BioAssays by Target

Select item 187436610.

Inhibition of L-type calcium channel phenylalkylamine site (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Targets:: Voltage-dependent L-type calcium channel subunit alpha-1C; ...
Total:: 4

Assay data:3 Tested

AID:: 1874366

Summary PubMed Citation Related BioAssays by Target

Select item 187433811.

Inhibition of human CaV1.2 channel

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:3 Tested

AID:: 1874338

Summary PubMed Citation Related BioAssays by Target

Select item 186220812.

Inhibition of human Cav1.2

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:2 Tested

AID:: 1862208

Summary PubMed Citation Related BioAssays by Target

Select item 186123513.

Inhibition of human Cav1.2

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1861235

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185759614.

Inhibition of Cav1.2 (unknown origin) cardiac ion channel by patch clamp assay

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1857596

Summary PubMed Citation Related BioAssays by Target

Select item 184518815.

Calcium Channel L-Type, Phenylalkylamine Eurofins-Panlabs radioligand binding assay

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1845188

Summary Related BioAssays by Target

Select item 183454216.

CAV1.2 Eurofins SafetyScreen (Other)

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1834542

Summary Related BioAssays by Target

Select item 183183817.

Inhibition of human Cav1.2 at 10 uM

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1831838

Summary PubMed Citation Related BioAssays by Target

Select item 183174418.

Inhibition of Cav1.2 (unknown origin) at 10 uM

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:1 Tested

AID:: 1831744

Summary PubMed Citation Related BioAssays by Target

Select item 182657319.

Inhibition of calcium channel, Type L (unknown origin) at 10 uM

Source:: ChEMBL

Protein Targets:: Voltage-dependent L-type calcium channel subunit alpha-1C; ...
Total:: 4

Assay data:1 Tested

AID:: 1826573

Summary PubMed Citation Related BioAssays by Target

Select item 182628520.

Inhibition of human Cav1.2 expressed in HEK293 cells at 30 uM by automated electrophysiology QPatch HT assay

Source:: ChEMBL

Protein Target:: Voltage-dependent L-type calcium channel subunit alpha-1C

Assay data:2 Tested

AID:: 1826285

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (14)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (146)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (9)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (65)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (304)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (13)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (515)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (11)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (479)
BioAssays extracted from the literature
NIH MLP (14)
BioAssays deposited by the NIH Molecular Libraries Program
Other (35)
BioAssays deposited by other experimentalists

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