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Inhibition of rat brain mTOR using GST-p70S6K fusion protein as substrate preincubated for 30 mins followed by ATP addition and measured after 30 mins by K-Lisa assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mTOR E2419K mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR L2427P mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR C1483Y mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR L1460P mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR S2215Y mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR S2215F mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19 nM)
Inhibition of mTOR in rat PC12 cells assessed as induction of autophagy at 500 nM after 48 hrs by MDC staining-based flow cytometric method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of rat derived mTOR using [gamma32P]ATP
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Reversible inhibition of mTOR (unknown origin) assessed as enzyme recovery measured after dilution in presence of ATP relative to untreated control
Inhibition of HGF induced mTOR activation in rat liver assessed as inhibition of S6RP phosphorylation at 100 mg/kg, ip 6 hrs prior to HGF stimulation by MSD analysis
Inhibition of HGF induced mTOR activation in rat liver assessed as inhibition of AKT phosphorylation at S473 at 100 mg/kg, ip 6 hrs prior to HGF stimulation by MSD analysis
Inhibition of HGF induced mTOR activation in rat liver assessed as inhibition of AKT phosphorylation at S473 at 30 mg/kg, ip 6 hrs prior to HGF stimulation by MSD analysis
Inhibition of rat brain mTOR assessed as p70S6K-GST protein phosphorylation after 30 mins by ELISA
Assay data:12 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISA
Assay data:18 Active, 10 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
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