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Inhibition of [3H]-PDBu binding to PKCalpha C1A domain (unknown origin) by competitive binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000749a PRKCA
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b PRKCA
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000704a PRKCA
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCA
Inhibition of PKCalpha (unknown origin) at 1 uM in presence of ATP at Km concentration by mobility shift assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PRKCA (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
Inhibition of PKCalpha (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKCalpha (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of PKCalpha (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:14 Tested
Inhibition of recombinant human full length PKCalpha assessed as residual activity at 1 uM using histone H1 as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric scintillation counting method relative to control
Inhibition of PKC (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PRKCA (unknown origin) at 1.0 uM relative to control
Inhibition of PRKCA (unknown origin) at 1 uM relative to control
Inhibition of human PKCalpha assessed as residual activity at 10 uM relative to control
Assay data:3 Tested
PKCalpha (h) Kinase panel
PKC?(h) Millipore kinase panel
Inhibition of PKCalpha (unknown origin)at 1 uM
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