BioAssay by Target (List) for Gene (Select 10018) - PubChem BioAssay - NCBI

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Select item 19194871.

AlphaLISA Assay from US Patent US11667652: "MCL1 inhibitors"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:204 Active, 193 Activity ≤ 1 nM, 204 Activity ≤ 1 µM, 204 Tested

AID:: 1919487

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19194292.

AlphaLISA assay from US Patent US11643400: "MCL-1 inhibitors"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:443 Active, 402 Activity ≤ 1 nM, 443 Activity ≤ 1 µM, 443 Tested

AID:: 1919429

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18588283.

Inhibition of Mcl-1/Bim (unknown origin) by fluorescence polarisation assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1858828

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18588204.

Inhibition of Bcl-xL/Bim (unknown origin) by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:2 Active, 3 Tested

AID:: 1858820

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18588195.

Inhibition of GST-tagged Mcl-1/Bim (unknown origin) incubated for 15 mins followed by Bim addition measured after 2 hrs by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1858819

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18588186.

Inhibition of GST-tagged Bcl-xL/Bim (unknown origin) incubated for 15 mins followed by Bim addition measured after 2 hrs by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1858818

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18588177.

Inhibition of Bcl-2/Bim (unknown origin) by ELISA method

Source:: ChEMBL

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 2

Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 1858817

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18588168.

Inhibition of Mcl-1/Bim (unknown origin) by ELISA method

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:6 Active, 3 Activity ≤ 1 µM, 7 Tested

AID:: 1858816

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18588069.

Binding affinity to Bcl-xL/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1858806

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185880310.

Binding affinity to GST-tagged Bcl-xL/5-FAM-tagged Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1858803

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184533711.

Inhibition of C-terminal His6-tagged recombinant human MCL-1 (171 to 327 residues/biotinylated Bim (51 to 76 residues) interaction incubated for 1 hrs followed by Bim addition and measured after 2 hrs by AlphaLISA assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1845337

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 181260212.

Inhibition of MCL1/Bim interaction in human MCF7 cells assessed as disruption of MCL1/Bim complex at 10 uM measured after 24 hrs by co-immunoprecipitation based western blot analysis relative to control

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:3 Tested

AID:: 1812602

Summary PubMed Citation Related BioAssays by Target

Select item 180660413.

Cell Free Mcl-1: Bim Affinity Assay (Mcl-1 HTRF) from US Patent US11364248: "Compounds that inhibit Mcl-1 protein"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:54 Active, 42 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested

AID:: 1806604

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180641114.

Cell Free Mcl-1:Bim Affinity Assay (Mcl-1 HTRF) from US Patent US11279712: "Macrocyclic compounds that inhibit MCL-1 protein"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:61 Active, 52 Activity ≤ 1 nM, 61 Activity ≤ 1 µM, 61 Tested

AID:: 1806411

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180640115.

Bim Binding Assays (Mcl-1 TR-FRET Assays (with 5% human serum) ) from US Patent US11274105: "Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:170 Active, 2 Activity ≤ 1 nM, 158 Activity ≤ 1 µM, 171 Tested

AID:: 1806401

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180640016.

Bim Binding Assays (Mcl-1 TR-FRET Assays) from US Patent US11274105: "Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:171 Active, 128 Activity ≤ 1 nM, 171 Activity ≤ 1 µM, 171 Tested

AID:: 1806400

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180627017.

Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay from US Patent US11224601: "Compounds that inhibits MCL-1 protein"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:812 Active, 676 Activity ≤ 1 nM, 812 Activity ≤ 1 µM, 812 Tested

AID:: 1806270

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180500518.

Fluorescence Polarization Assay from US Patent US10829488: "N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors"

Source:: BindingDB

Protein Targets:: BH3-interacting domain death agonist; ...
Total:: 2

Assay data:22 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested

AID:: 1805005

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180454419.

Binding AlphaLISA Assay from US Patent US10703733: "MCL-1 inhibitors"

Source:: BindingDB

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:445 Active, 402 Activity ≤ 1 nM, 445 Activity ≤ 1 µM, 445 Tested

AID:: 1804544

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 171582420.

Inhibition of Mcl1-Bim interaction in human SK-MEL-28 cells at 30 uM incubated for 24 hrs by immunoprecipitation assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1715824

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (9)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Chemical Probes (2)
BioAssays with compounds reported as validated chemical probes

Active Compounds (34)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (10)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (20)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (3)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (27)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (11)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (38)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (10)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (29)
BioAssays extracted from the literature
NIH MLP (9)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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