Entry - *616611 - LONG INTERGENIC NONCODING RNA 461; LINC00461 - OMIM

 
 
* 616611

LONG INTERGENIC NONCODING RNA 461; LINC00461


Alternative titles; symbols

lincRNA 461
VISUAL CORTEX-EXPRESSED GENE; VISC


HGNC Approved Gene Symbol: MIR9-2HG

Cytogenetic location: 5q14.3     Genomic coordinates (GRCh38): 5:88,538,266-88,691,041 (from NCBI)


TEXT

▼ Description

Long intergenic noncoding RNAs (lincRNAs), like LINC00461, are predicted to function in gene regulation (Oliver et al., 2015).


▼ Cloning and Expression

Oliver et al. (2015) cloned 3 splice variants of mouse Linc00461, which they called Visc. Vsc1, but not Visc2 or Visc3, includes the precursor for the microRNA-9-2 (MIR9-2; 611187) within its terminal 3-prime exon. Database analysis revealed close orthologs of Visc1 in human, cow, and opossum, but not in birds, lizard, and frog. Visc2 orthologs were present in human and opossum. In situ hybridization detected high expression of Visc2 and lower expression of Visc1 and Visc3 in developing mouse cortex, but not in other organs. In situ hybridization of developing opossum and human brain revealed similar expression of VISC2.


▼ Gene Structure

Oliver et al. (2015) determined that the LINC00461 gene has at least 4 exons. The terminal 3-prime exon hosts the MIR9-2 gene.


▼ Mapping

Hartz (2015) mapped the LINC00461 gene to chromosome 5q14.3 based on an alignment of the LINC00461 sequence (GenBank AK091356) with the genomic sequence (GRCh38).

Oliver et al. (2015) reported that the mouse Linc00461 gene maps to chromosome 13, between the Mef2c (600662) and Tmem161b genes.


▼ Animal Model

Oliver et al. (2015) found that knockout of Visc2 expression in mice resulted in no measurable physical, behavioral, or cytologic phenotypes. Visc1 was expressed in Visc2-knockout mice, although expression of Mir9-2 was significantly reduced.


▼ REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 10/23/2015.

  2. Oliver, P. L., Chodroff, R. A., Gosal, A., Edwards, B., Cheung, A. F. P., Gomez-Rodriguez, J., Elliot, G., Garrett, L. J., Lickiss, T., Szele, F., Green, E. D., Molnar, Z., Ponting, C. P. Disruption of Visc-2, a brain-expressed conserved long noncoding RNA, does not elicit an overt anatomical or behavioral phenotype. Cereb. Cortex 25: 3572-3585, 2015. [PubMed: 25209608, images, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 10/23/2015
Edit History:
mgross : 10/23/2015

* 616611

LONG INTERGENIC NONCODING RNA 461; LINC00461


Alternative titles; symbols

lincRNA 461
VISUAL CORTEX-EXPRESSED GENE; VISC


HGNC Approved Gene Symbol: MIR9-2HG

Cytogenetic location: 5q14.3     Genomic coordinates (GRCh38): 5:88,538,266-88,691,041 (from NCBI)


TEXT

Description

Long intergenic noncoding RNAs (lincRNAs), like LINC00461, are predicted to function in gene regulation (Oliver et al., 2015).


Cloning and Expression

Oliver et al. (2015) cloned 3 splice variants of mouse Linc00461, which they called Visc. Vsc1, but not Visc2 or Visc3, includes the precursor for the microRNA-9-2 (MIR9-2; 611187) within its terminal 3-prime exon. Database analysis revealed close orthologs of Visc1 in human, cow, and opossum, but not in birds, lizard, and frog. Visc2 orthologs were present in human and opossum. In situ hybridization detected high expression of Visc2 and lower expression of Visc1 and Visc3 in developing mouse cortex, but not in other organs. In situ hybridization of developing opossum and human brain revealed similar expression of VISC2.


Gene Structure

Oliver et al. (2015) determined that the LINC00461 gene has at least 4 exons. The terminal 3-prime exon hosts the MIR9-2 gene.


Mapping

Hartz (2015) mapped the LINC00461 gene to chromosome 5q14.3 based on an alignment of the LINC00461 sequence (GenBank AK091356) with the genomic sequence (GRCh38).

Oliver et al. (2015) reported that the mouse Linc00461 gene maps to chromosome 13, between the Mef2c (600662) and Tmem161b genes.


Animal Model

Oliver et al. (2015) found that knockout of Visc2 expression in mice resulted in no measurable physical, behavioral, or cytologic phenotypes. Visc1 was expressed in Visc2-knockout mice, although expression of Mir9-2 was significantly reduced.


REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 10/23/2015.

  2. Oliver, P. L., Chodroff, R. A., Gosal, A., Edwards, B., Cheung, A. F. P., Gomez-Rodriguez, J., Elliot, G., Garrett, L. J., Lickiss, T., Szele, F., Green, E. D., Molnar, Z., Ponting, C. P. Disruption of Visc-2, a brain-expressed conserved long noncoding RNA, does not elicit an overt anatomical or behavioral phenotype. Cereb. Cortex 25: 3572-3585, 2015. [PubMed: 25209608] [Full Text: https://doi.org/10.1093/cercor/bhu196]


Creation Date:
Patricia A. Hartz : 10/23/2015

Edit History:
mgross : 10/23/2015



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 3, 2024