Alternative titles; symbols
HGNC Approved Gene Symbol: UBTD2
Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,209,646-172,284,117 (from NCBI)
From large scale sequencing of a human dendritic cell cDNA library, Liu et al. (2003) identified a novel ubiquitin-like protein, which they designated dendritic cell-derived ubiquitin-like protein (DCUBP). The deduced 106-amino acid DCUBP protein has a calculated molecular mass of 12.2 kD. Its UBQ domain shares 28.6% identity with that of ubiquitin (see 191339); however, it does not possess the C-terminal Gly-Gly that is required for ubiquitination, suggesting that it may not be involved in protein degradation. Immunolocalization indicated that DCUBP localizes to cytoplasm, especially in the mitochondrion. Using Northern blot analysis and RT-PCR, Liu et al. (2003) observed no detectable DCUBP bands in multiple human adult normal tissues. However, the DCUBP transcript was enriched in multiple tumor cell lines, including A431, MCF7, Lovo, HT29, PC-3, SMMC7721, and U251. Liu et al. (2003) found that DCUBP expression was significantly decreased in tumor necrosis-related apoptosis-inducing ligand (TRAIL)- and all-trans retinoid acid agonist (ATRA)-stimulated HL60 cells. Liu et al. (2003) suggested that DCUBP may be involved in TRAIL-induced apoptosis or retinoid acid receptor-alpha signaling processes.
By genomic sequence analysis, Liu et al. (2003) determined that the UBTD2 gene maps to chromosome 5q35.
Liu, S., An, H., Li, N., Yu, Y., Lin, N., Wan, T., Zhang, M., Wang, W., Cao, X. Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. Biochem. Biophys. Res. Commun. 300: 800-805, 2003. [PubMed: 12507522] [Full Text: https://doi.org/10.1016/s0006-291x(02)02913-3]