Alternative titles; symbols
HGNC Approved Gene Symbol: H1-0
Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,805,229-37,807,432 (from NCBI)
For background information on histones, histone gene clusters, and the H1 histone family, see HIST1H1A (142709).
Doenecke and Tonjes (1986) cloned the human H1.0 gene.
Marzluff et al. (2002) noted that H1F0 is a replacement H1 histone whose transcription is independent of DNA replication. Unlike the transcripts for replication-dependent histones, transcripts for replacement histones, including that for H1F0, are polyadenylated. Marzluff et al. (2002) stated that H1F0 is expressed at high levels during terminal differentiation.
See HIST1H1A (142709) for functional information on H1 histones.
By PCR analysis of chromosomal DNA from a panel of human/rodent somatic cell hybrids, Albig et al. (1993) demonstrated that the H1.0 gene maps to chromosome 22. By fluorescence in situ hybridization, they localized the gene to 22q13.1. Thus, unlike the other H1 genes mapped by Albig et al. (1993), H1.0 lies outside the histone gene cluster on chromosome 6.
By genomic sequence analysis, Marzluff et al. (2002) determined that nearly all replication-dependent histone genes are clustered on chromosomes 6p22-p21, 1q21, and 1q42. In contrast, replication-independent histone genes, such as H1F0, lie outside of these clusters.
Albig, W., Drabent, B., Kunz, J., Kalff-Suske, M., Grzeschik, K.-H., Doenecke, D. All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. Genomics 16: 649-654, 1993. [PubMed: 8325638] [Full Text: https://doi.org/10.1006/geno.1993.1243]
Doenecke, D., Tonjes, R. Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. J. Molec. Biol. 187: 461-464, 1986. [PubMed: 3084796] [Full Text: https://doi.org/10.1016/0022-2836(86)90446-8]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966]