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    Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 2, mRNA

    NCBI Reference Sequence: NM_001005862.1

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      Analyze this sequence

      • Run BLAST
        Find regions of similarity between this sequence and other sequences using BLAST.
      • Pick Primers
        Design and test primers for this sequence using Primer-BLAST.
      • Highlight Sequence Features
        Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
      • Find in this Sequence
        Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

      Articles about the ERBB2 gene

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      Pathways for the ERBB2 gene

      • Downregulation of ERRB2:ERBB3 signaling
        Downregulation of ERRB2:ERBB3 signalingLevel of plasma membrane ERBB3 is regulated by E3 ubiquitin ligase RNF41 (also known as NRDP1), which binds and ubiquitinates both inactive and activated ERBB3, targeting it for degradation (Cao et al ... [bsid530740]
      • GRB7 events in ERBB2 signaling
        GRB7 events in ERBB2 signalingHeterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262), but the exact downstream signaling of this ... [bsid530739]
      • PLCG1 events in ERBB2 signaling
        PLCG1 events in ERBB2 signalingActivation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 1999 ... [bsid530738]
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      Variation viewer

      Reference sequence information

      • RefSeq alternative splicing
        See the other reference mRNA sequence splice variant for the ERBB2 gene (NM_004448.2).
      • RefSeq protein product
        See the reference protein sequence for receptor tyrosine-protein kinase erbB-2 isoform b (NP_001005862.1).

      More about the ERBB2 gene

      Homologs of the ERBB2 gene

      LinkOut to external resources

      • Ensembl [Ensembl]
        Ensembl
      • Ensembl [Ensembl]
        Ensembl
      • ERBB2 expression clone [OriGene Technologies]
        ERBB2 expression clone
        OriGene Technologies
      • protein and peptide [ExactAntigen/Labome]
        protein and peptide
        ExactAntigen/Labome
      • antibody [ExactAntigen/Labome]
        antibody
        ExactAntigen/Labome
      • others [ExactAntigen/Labome]
        others
        ExactAntigen/Labome
      • siRNA and shRNA [ExactAntigen/Labome]
        siRNA and shRNA
        ExactAntigen/Labome
      • ELISA and assay kit [ExactAntigen/Labome]
        ELISA and assay kit
        ExactAntigen/Labome
      • biochemicals [ExactAntigen/Labome]
        biochemicals
        ExactAntigen/Labome
      • cDNA clone [ExactAntigen/Labome]
        cDNA clone
        ExactAntigen/Labome
      • antibody review [ExactAntigen/Labome]
        antibody review
        ExactAntigen/Labome
      • Order full-length cDNA clone [GeneCopoeia Inc.]
        Order full-length cDNA clone
        GeneCopoeia Inc.
      • Order full-length cDNA clone [Harvard Institute of Proteomi...]
        Order full-length cDNA clone
        Harvard Institute of Proteomics
      • TaqMan® Genotyping Assays [TaqMan probe and primer sets ...]
        TaqMan® Genotyping Assays
        TaqMan probe and primer sets (Assays) and RNAi products from Life Technologies
      • Ambion siRNA [TaqMan probe and primer sets ...]
        Ambion siRNA
        TaqMan probe and primer sets (Assays) and RNAi products from Life Technologies
      • TaqMan® Gene Expression Assays [TaqMan probe and primer sets ...]
        TaqMan® Gene Expression Assays
        TaqMan probe and primer sets (Assays) and RNAi products from Life Technologies
      • imaGenes [imaGenes]
        imaGenes
      • UCSC Genome Browser [UCSC Genome Browser]
        UCSC Genome Browser

      Related information

      • Related Sequences
        Nucleotide sequences related by sequence similarity (BLAST) score to the current records.
      • BioSystems
        BioSystems
      • CCDS
        Link to Consensus CDS
      • Components (Core)
        Nucleotide records that are the components of the assembled sequence records in the current set.
      • Components (EST)
        Expressed Sequence Tag (EST) records that are components of assembled nucleotide records in the current set.
      • Full text in PMC
        Free full-text articles in PubMed central that cite nucleotide records in the current set.
      • Gene
        Gene records referencing the current sequence records. Sequences included in Gene are added manually by NCBI.
      • Gene Genotype
        Genotype reports for single nucleotide polymorphisms (SNPs) associated with the current records.
      • GeneView in dbSNP
        Geneview in dbSNP showing nucleotide polymorphisms (SNPs) mapped to the genes associated with the current records.
      • Map Viewer
        Graphical Map Viewer display of the current nucleotide records in assembled genomes. Records may be part of the assembly or mapped as alignment-based annotation.
      • Master
        Genomic sequence records that have the current mRNA records as annotated features marking the exons of genes.
      • OMIM
        Online Mendelian Inheritance in Man articles that refer to nucleotide records in the current set.
      • Probe
        Probe database records for genotyping, gene expression, SNP discovery, genome mapping, and gene silencing reagents that target the genes and gene products associated with the current nucleotide sequence records.
      • Protein
        Protein translations of coding regions from sequence records in the current set.
      • PubMed
        PubMed articles that cite nucleotide records in the current set. These are articles that report the International Nucleotide Database Collaboration (DDBJ, EMBL, GenBank) data. These articles are also linked to Reference Sequences derived from these records.
      • PubMed (RefSeq)
        PubMed articles that are cited in NCBI Reference Sequences in the present set.
      • PubMed (Weighted)
        PubMed articles associated with the current nucleotide records through the Gene database. These articles include Reference into Function, citations in related OMIM, and those associated with sequences in the Gene record.
      • SNP
        Single nucleotide polymorphisms (SNPs) mapped to the current records. Links may be provided through SNP data submission or through annotations on the nucleotide record.
      • Taxonomy
        NCBI Taxonomy entries and classification information for the source organisms of the current set of records.
      • UniGene
        UniGene clusters of expressed sequences that contain mRNA records in the current set.
      • UniSTS
        Genetic, physical, and sequence mapping reagents in the UniSTS database mapped on the current nucleotide records.
      • GEO Profiles
        GEO Profile records associated with Nucleotide record

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