Coproporphyrinogen Oxidase

An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.

Year introduced: 1991(1976)

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Tree Number(s): D08.811.682.660.250

MeSH Unique ID: D003304

Registry Number: EC 1.3.3.3

Entry Terms:

• Oxidase, Coproporphyrinogen
• Coproporphyrinogen III Oxidases
• III Oxidases, Coproporphyrinogen
• Oxidases, Coproporphyrinogen III
• Coproporphyrinogenase

Previous Indexing:

• Carboxy-Lyases (1972-1974)
• Coproporphyrins (1975)
• Oxidoreductases (1975)
• Porphyrins (1972-1974)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Oxidoreductases
Oxidoreductases Acting on CH-CH Group Donors
Coproporphyrinogen Oxidase