Trimethoprim

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Year introduced: 1974 (1972)

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Tree Number(s): D03.383.742.906

MeSH Unique ID: D014295

Registry Number: AN164J8Y0X

Entry Terms:

• Trimpex
• Proloprim

Previous Indexing:

• Anti-Infective Agents (1966-1971)
• Folic Acid Antagonists (1966-1971)
• Pyrimidines (1966-1971)

See Also:

• Trimethoprim Resistance

Pharmacologic Action:

• Anti-Infective Agents, Urinary
• Antimalarials
• Folic Acid Antagonists
• Anti-Dyskinesia Agents
• Cytochrome P-450 CYP2C8 Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, 1-Ring
Pyrimidines
Trimethoprim
Trimethoprim, Sulfamethoxazole Drug Combination