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Mixed Connective Tissue Disease

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.

Year introduced: 1979

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Tree Number(s): C17.300.540

MeSH Unique ID: D008947

Entry Terms:

  • Connective Tissue Disease, Mixed
  • Sharp Syndrome
  • Syndrome, Sharp
  • MCTD

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