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Malignant tumor of prostate

MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
Synonyms: Prostate cancer
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Malignant tumor of prostate (399068003); Malignant prostatic tumor (399068003); CA - Cancer of prostate (399068003); Cancer of prostate (399068003)
 
Genes: CHEK2; MAD1L1; PTEN; MXI1; MSR1; CD82; HIP1; KLF6; CDH1; BRCA2; ZFHX3; AR
Cytogenetic locations: 10p15.2; 10q23.31; 10q25.2; 11p11.2; 13q13.1; 16q22.1; 16q22.2-22.3; 22q12.1; 7p22.3; 7q11.23; 8p22; Xq12
OMIM: 176807

Definition

A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas. -- 2003 [from NCI]

Clinical features

Prostate cancer
MedGen UID:
506673
Concept ID:
CN167851
Finding
A cancer of the `prostate` (FMA:9600).

Term Hierarchy

Professional guidelines

PubMed

Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group
Genet Med 2014 Apr;16(4):338-46. Epub 2013 Sep 26 doi: 10.1038/gim.2013.141. [Epub ahead of print] PMID: 24071797
Sturgeon CM, Duffy MJ, Stenman UH, Lilja H, Brünner N, Chan DW, Babaian R, Bast RC Jr, Dowell B, Esteva FJ, Haglund C, Harbeck N, Hayes DF, Holten-Andersen M, Klee GG, Lamerz R, Looijenga LH, Molina R, Nielsen HJ, Rittenhouse H, Semjonow A, Shih IeM, Sibley P, Sölétormos G, Stephan C, Sokoll L, Hoffman BR, Diamandis EP; National Academy of Clinical Biochemistry
Clin Chem 2008 Dec;54(12):e11-79. doi: 10.1373/clinchem.2008.105601. PMID: 19042984

External

Gene Expression Analysis for Prostate Cancer Management

Recent clinical studies

Etiology

Tidehag V, Hammarsten P, Egevad L, Granfors T, Stattin P, Leanderson T, Wikström P, Josefsson A, Hägglöf C, Bergh A
Eur J Cancer 2014 Jul;50(10):1829-35. Epub 2014 Apr 10 doi: 10.1016/j.ejca.2014.03.278. [Epub ahead of print] PMID: 24726733
Zolochevska O, Ellis J, Parelkar S, Chan-Seng D, Emrick T, Wei J, Patrikeev I, Motamedi M, Figueiredo ML
Hum Gene Ther 2013 Dec;24(12):970-81. Epub 2013 Nov 6 doi: 10.1089/hum.2013.091. [Epub ahead of print] PMID: 24028178Free PMC Article
Chen CL, Mahalingam D, Osmulski P, Jadhav RR, Wang CM, Leach RJ, Chang TC, Weitman SD, Kumar AP, Sun L, Gaczynska ME, Thompson IM, Huang TH
Prostate 2013 Jun;73(8):813-26. Epub 2012 Dec 31 doi: 10.1002/pros.22625. [Epub ahead of print] PMID: 23280481
He H, Osunkoya AO, Carver P, Falzarano S, Klein E, Magi-Galluzzi C, Zhou M
BJU Int 2012 Dec;110(11 Pt B):E751-5. Epub 2012 Oct 9 doi: 10.1111/j.1464-410X.2012.11557.x. [Epub ahead of print] PMID: 23046279
Murray NP, Reyes E, Tapia P, Orellana N, Dueñas R, Fuentealba C, Badinez L
Arch Esp Urol 2011 Dec;64(10):961-71. PMID: 22228894

Diagnosis

Tidehag V, Hammarsten P, Egevad L, Granfors T, Stattin P, Leanderson T, Wikström P, Josefsson A, Hägglöf C, Bergh A
Eur J Cancer 2014 Jul;50(10):1829-35. Epub 2014 Apr 10 doi: 10.1016/j.ejca.2014.03.278. [Epub ahead of print] PMID: 24726733
Bennett NC, Hooper JD, Johnson DW, Gobe GC
Prostate 2014 May;74(5):478-87. Epub 2013 Dec 24 doi: 10.1002/pros.22767. [Epub ahead of print] PMID: 24375805
Flatley B, Wilmott KG, Malone P, Cramer R
Prostate 2014 Jan;74(1):103-11. Epub 2013 Sep 30 doi: 10.1002/pros.22736. [Epub ahead of print] PMID: 24115268
Chen CL, Mahalingam D, Osmulski P, Jadhav RR, Wang CM, Leach RJ, Chang TC, Weitman SD, Kumar AP, Sun L, Gaczynska ME, Thompson IM, Huang TH
Prostate 2013 Jun;73(8):813-26. Epub 2012 Dec 31 doi: 10.1002/pros.22625. [Epub ahead of print] PMID: 23280481
He H, Osunkoya AO, Carver P, Falzarano S, Klein E, Magi-Galluzzi C, Zhou M
BJU Int 2012 Dec;110(11 Pt B):E751-5. Epub 2012 Oct 9 doi: 10.1111/j.1464-410X.2012.11557.x. [Epub ahead of print] PMID: 23046279

Therapy

Mostaghel EA, Nelson PS, Lange P, Lin DW, Taplin ME, Balk S, Ellis W, Kantoff P, Marck B, Tamae D, Matsumoto AM, True LD, Vessella R, Penning T, Hunter Merrill R, Gulati R, Montgomery B
J Clin Oncol 2014 Jan 20;32(3):229-37. Epub 2013 Dec 9 doi: 10.1200/JCO.2012.48.6431. [Epub ahead of print] PMID: 24323034Free PMC Article
Flatley B, Wilmott KG, Malone P, Cramer R
Prostate 2014 Jan;74(1):103-11. Epub 2013 Sep 30 doi: 10.1002/pros.22736. [Epub ahead of print] PMID: 24115268
Jenney M, Oberlin O, Audry G, Stevens MC, Rey A, Merks JH, Kelsey A, Gallego S, Haie-Meder C, Martelli H
Pediatr Blood Cancer 2014 Feb;61(2):217-22. Epub 2013 Aug 29 doi: 10.1002/pbc.24727. [Epub ahead of print] PMID: 23997024
Zolochevska O, Ellis J, Parelkar S, Chan-Seng D, Emrick T, Wei J, Patrikeev I, Motamedi M, Figueiredo ML
Hum Gene Ther 2013 Dec;24(12):970-81. Epub 2013 Nov 6 doi: 10.1089/hum.2013.091. [Epub ahead of print] PMID: 24028178Free PMC Article
Lamoureux F, Thomas C, Crafter C, Kumano M, Zhang F, Davies BR, Gleave ME, Zoubeidi A
Clin Cancer Res 2013 Feb 15;19(4):833-44. Epub 2012 Dec 20 doi: 10.1158/1078-0432.CCR-12-3114. [Epub ahead of print] PMID: 23258740

Prognosis

Tidehag V, Hammarsten P, Egevad L, Granfors T, Stattin P, Leanderson T, Wikström P, Josefsson A, Hägglöf C, Bergh A
Eur J Cancer 2014 Jul;50(10):1829-35. Epub 2014 Apr 10 doi: 10.1016/j.ejca.2014.03.278. [Epub ahead of print] PMID: 24726733
Liu D, Tao T, Xu B, Chen S, Liu C, Zhang L, Lu K, Huang Y, Jiang L, Zhang X, Huang X, Zhang L, Han C, Chen M
Biochem Biophys Res Commun 2014 Feb 28;445(1):151-6. Epub 2014 Jan 31 doi: 10.1016/j.bbrc.2014.01.140. [Epub ahead of print] PMID: 24491557
Luo W, Hu Q, Wang D, Deeb KK, Ma Y, Morrison CD, Liu S, Johnson CS, Trump DL
Oncotarget 2013 Sep;4(9):1472-83. PMID: 23978847Free PMC Article
Pruitt FL, He Y, Franco OE, Jiang M, Cates JM, Hayward SW
Prostate 2013 Apr;73(5):476-88. Epub 2012 Sep 19 doi: 10.1002/pros.22589. [Epub ahead of print] PMID: 22996917Free PMC Article
He H, Osunkoya AO, Carver P, Falzarano S, Klein E, Magi-Galluzzi C, Zhou M
BJU Int 2012 Dec;110(11 Pt B):E751-5. Epub 2012 Oct 9 doi: 10.1111/j.1464-410X.2012.11557.x. [Epub ahead of print] PMID: 23046279

Clinical prediction guides

Tidehag V, Hammarsten P, Egevad L, Granfors T, Stattin P, Leanderson T, Wikström P, Josefsson A, Hägglöf C, Bergh A
Eur J Cancer 2014 Jul;50(10):1829-35. Epub 2014 Apr 10 doi: 10.1016/j.ejca.2014.03.278. [Epub ahead of print] PMID: 24726733
Körner M, Waser B, Rehmann R, Reubi JC
Prostate 2014 Feb;74(2):217-24. Epub 2013 Oct 22 doi: 10.1002/pros.22743. [Epub ahead of print] PMID: 24150752
Af Hällström TM, Zhao H, Tian J, Rantanen V, Reese SW, Nolley R, Laiho M, Peehl DM
J Urol 2014 Mar;191(3):842-9. Epub 2013 Sep 11 doi: 10.1016/j.juro.2013.09.007. [Epub ahead of print] PMID: 24035881Free PMC Article
Panagopoulos K, Cross-Knorr S, Dillard C, Pantazatos D, Del Tatto M, Mills D, Goldstein L, Renzulli J, Quesenberry P, Chatterjee D
Mol Cancer 2013 Oct 8;12(1):118. doi: 10.1186/1476-4598-12-118. [Epub ahead of print] PMID: 24103426Free PMC Article
Luo W, Hu Q, Wang D, Deeb KK, Ma Y, Morrison CD, Liu S, Johnson CS, Trump DL
Oncotarget 2013 Sep;4(9):1472-83. PMID: 23978847Free PMC Article

Recent systematic reviews

Carvalho FL, Simons BW, Eberhart CG, Berman DM
Prostate 2014 Jun;74(9):933-45. Epub 2014 Apr 16 doi: 10.1002/pros.22811. [Epub ahead of print] PMID: 24737393
Mostaghel EA, Nelson PS, Lange P, Lin DW, Taplin ME, Balk S, Ellis W, Kantoff P, Marck B, Tamae D, Matsumoto AM, True LD, Vessella R, Penning T, Hunter Merrill R, Gulati R, Montgomery B
J Clin Oncol 2014 Jan 20;32(3):229-37. Epub 2013 Dec 9 doi: 10.1200/JCO.2012.48.6431. [Epub ahead of print] PMID: 24323034Free PMC Article
Jin G, Su DK, Luo NB, Liu LD, Zhu X, Huang XY
J Comput Assist Tomogr 2013 Mar-Apr;37(2):195-202. doi: 10.1097/RCT.0b013e3182801ae1. PMID: 23493208
Cooper SC, Trudgill NJ
Cancer Causes Control 2012 Jun;23(6):819-25. PMID: 24251326
Botelho F, Pina F, Lunet N
Eur J Cancer Prev 2010 Sep;19(5):385-92. doi: 10.1097/CEJ.0b013e32833b48e1. PMID: 20502342

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