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Elevated urinary epinephrine

MedGen UID:
358197
Concept ID:
C1868393
Finding
Synonyms: Increased urinary epinephrine
 
HPO: HP:0003639

Term Hierarchy

Conditions with this feature

Multiple endocrine neoplasia, type 2a
MedGen UID:
9958
Concept ID:
C0025268
Neoplastic Process
Multiple endocrine neoplasia type 2 (MEN 2) is classified into three subtypes: MEN 2A, FMTC (familial medullary thyroid carcinoma), and MEN 2B. All three subtypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN 2A and MEN 2B have an increased risk for pheochromocytoma; MEN 2A has an increased risk for parathyroid adenoma or hyperplasia. Additional features in MEN 2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and an asthenic ‘marfanoid’ body habitus. MTC typically occurs in early childhood in MEN 2B, early adulthood in MEN 2A, and middle age in FMTC.
Multiple endocrine neoplasia, type 2b
MedGen UID:
9959
Concept ID:
C0025269
Neoplastic Process
Multiple endocrine neoplasia type 2 (MEN 2) is classified into three subtypes: MEN 2A, FMTC (familial medullary thyroid carcinoma), and MEN 2B. All three subtypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN 2A and MEN 2B have an increased risk for pheochromocytoma; MEN 2A has an increased risk for parathyroid adenoma or hyperplasia. Additional features in MEN 2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and an asthenic ‘marfanoid’ body habitus. MTC typically occurs in early childhood in MEN 2B, early adulthood in MEN 2A, and middle age in FMTC.

Recent clinical studies

Etiology

van Hulsteijn LT, van Duinen N, Romijn JA, Smit JW, Corssmit EP
Int J Biol Markers 2012 Jul 19;27(2):e160-3. doi: 10.5301/JBM.2012.9312. PMID: 22653742
Davidson DF, Hammond PJ, Murphy D, Carachi R
Ann Clin Biochem 2011 Jul;48(Pt 4):358-66. Epub 2011 Jun 13 doi: 10.1258/acb.2011.011023. [Epub ahead of print] PMID: 21670092
Oei TP, Dingle GA, McCarthy M
Behav Cogn Psychother 2010 Jul;38(4):479-83. Epub 2010 Mar 26 doi: 10.1017/S1352465810000093. [Epub ahead of print] PMID: 20338081
Lee ZS, Critchley JA, Tomlinson B, Young RP, Thomas GN, Cockram CS, Chan TY, Chan JC
Metabolism 2001 Feb;50(2):135-43. doi: 10.1053/meta.2001.19502. PMID: 11229419
Guttler RB, Shaw JW, Otis CL, Nicologg JT
J Clin Endocrinol Metab 1975 Oct;41(4):707-11. doi: 10.1210/jcem-41-4-707. PMID: 170297

Diagnosis

Davidson DF, Bradshaw N, Perry CG, Lindsay R, Freel EM
Ann Clin Biochem 2012 Sep;49(Pt 5):486-90. Epub 2012 Aug 22 doi: 10.1258/acb.2012.012021. [Epub ahead of print] PMID: 22914444
van Hulsteijn LT, van Duinen N, Romijn JA, Smit JW, Corssmit EP
Int J Biol Markers 2012 Jul 19;27(2):e160-3. doi: 10.5301/JBM.2012.9312. PMID: 22653742
Christensen TT, Frystyk J, Poulsen PL
Scand J Clin Lab Invest 2011 Dec;71(8):695-700. Epub 2011 Oct 24 doi: 10.3109/00365513.2011.622410. [Epub ahead of print] PMID: 22023043
Davidson DF, Hammond PJ, Murphy D, Carachi R
Ann Clin Biochem 2011 Jul;48(Pt 4):358-66. Epub 2011 Jun 13 doi: 10.1258/acb.2011.011023. [Epub ahead of print] PMID: 21670092
de Jong WH, Post WJ, Kerstens MN, de Vries EG, Kema IP
J Clin Endocrinol Metab 2010 Jun;95(6):2851-5. Epub 2010 Apr 9 doi: 10.1210/jc.2009-2589. [Epub ahead of print] PMID: 20382681

Therapy

Davidson DF, Hammond PJ, Murphy D, Carachi R
Ann Clin Biochem 2011 Jul;48(Pt 4):358-66. Epub 2011 Jun 13 doi: 10.1258/acb.2011.011023. [Epub ahead of print] PMID: 21670092
James GD, Berge-Landry Hv Hv, Valdimarsdottir HB, Montgomery GH, Bovbjerg DH
Psychoneuroendocrinology 2004 Aug;29(7):831-8. doi: 10.1016/S0306-4530(03)00150-1. PMID: 15177698
Ratheiser KM, Brillon DJ, Campbell RG, Matthews DE
Am J Clin Nutr 1998 Nov;68(5):1046-52. PMID: 9808221
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Am J Hypertens 1996 Sep;9(9):902-8. PMID: 8879347
Feldman JM
J Clin Pharmacol 1987 Apr;27(4):288-92. PMID: 3680586

Prognosis

Erem C, Fidan M, Civan N, Cobanoglu U, Kangul F, Nuhoglu I, Alhan E
Blood Press 2014 Feb;23(1):64-9. Epub 2013 May 27 doi: 10.3109/08037051.2013.796103. [Epub ahead of print] PMID: 23705630
Przybylowski P, Koc-Zorawska E, Malyszko JS, Mysliwiec M, Malyszko J
Transplant Proc 2013 Jan-Feb;45(1):394-6. doi: 10.1016/j.transproceed.2012.02.042. PMID: 23375328
Oei TP, Dingle GA, McCarthy M
Behav Cogn Psychother 2010 Jul;38(4):479-83. Epub 2010 Mar 26 doi: 10.1017/S1352465810000093. [Epub ahead of print] PMID: 20338081
Jeevanandam M, Ramias L, Schiller WR
J Trauma 1991 Mar;31(3):334-41. PMID: 1900537
Kortelainen ML, Huttunen P, Lapinlampi T
Forensic Sci Int 1990 Nov;48(1):103-10. PMID: 2279717

Clinical prediction guides

Przybylowski P, Koc-Zorawska E, Malyszko JS, Mysliwiec M, Malyszko J
Transplant Proc 2013 Jan-Feb;45(1):394-6. doi: 10.1016/j.transproceed.2012.02.042. PMID: 23375328
Otte C, Neylan TC, Pipkin SS, Browner WS, Whooley MA
Am J Psychiatry 2005 Nov;162(11):2139-45. doi: 10.1176/appi.ajp.162.11.2139. PMID: 16263855Free PMC Article
McCaffery JM, Muldoon MF, Bachen EA, Jennings JR, Manuck SB
Biol Psychol 2000 Feb;52(1):53-69. PMID: 10686372
Mazzeo RS, Wolfel EE, Butterfield GE, Reeves JT
Metabolism 1994 Oct;43(10):1226-32. PMID: 7934973
Guttler RB, Shaw JW, Otis CL, Nicologg JT
J Clin Endocrinol Metab 1975 Oct;41(4):707-11. doi: 10.1210/jcem-41-4-707. PMID: 170297

Recent systematic reviews

Häuser W, Urrútia G, Tort S, Uçeyler N, Walitt B
Cochrane Database Syst Rev 2013 Jan 31;1:CD010292. doi: 10.1002/14651858.CD010292. PMID: 23440848
He FJ, MacGregor GA
Cochrane Database Syst Rev 2004;(3):CD004937. doi: 10.1002/14651858.CD004937. PMID: 15266549
Luton JP, Martinez M, Coste J, Bertherat J
Eur J Endocrinol 2000 Jul;143(1):111-7. PMID: 10870039

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