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Autonomic erectile dysfunction

MedGen UID:
358232
Concept ID:
C1868524
Finding
Synonyms: Impotence due to autonomic dysfunction
 
HPO: HP:0008652

Term Hierarchy

Conditions with this feature

Leukodystrophy, adult-onset, autosomal dominant
MedGen UID:
356995
Concept ID:
C1868512
Disease or Syndrome
Autosomal dominant adult-onset demyelinating leukodystrophy is a slowly progressive and fatal disorder that presents in the fourth or fifth decade of life and is characterized clinically by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. ADLD differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis (summary by Padiath et al., 2006). Characteristic MRI findings include T2-weighted hyperintense changes in the upper corticospinal tract and cerebellar peduncles, with later development of confluent white matter changes in the frontoparietal area with relative sparing of the periventricular white matter (summary by Schuster et al., 2011).

Recent clinical studies

Etiology

Burnett AL, Sezen SF, Hoke A, Caggiano AO, Iaci J, Lagoda G, Musicki B, Bella AJ
J Sex Med 2015 Apr;12(4):897-905. Epub 2015 Jan 30 doi: 10.1111/jsm.12834. [Epub ahead of print] PMID: 25639458Free PMC Article
Umul M, Altay AB, Bademkiran F, Turna B, Semerci MB, Apaydin E, Cikili N
Turk J Med Sci 2014;44(4):681-6. PMID: 25551942
Harte CB
J Sex Med 2014 May;11(5):1230-9. Epub 2014 Feb 27 doi: 10.1111/jsm.12486. [Epub ahead of print] PMID: 24576257
Roshanzamir S, Dabbaghmanesh A, Ashraf A
Burns 2014 Jun;40(4):624-9. Epub 2013 Dec 3 doi: 10.1016/j.burns.2013.08.033. [Epub ahead of print] PMID: 24309204
Dogru MT, Basar MM
Int Urol Nephrol 2010 Sep;42(3):589-96. Epub 2009 Oct 29 doi: 10.1007/s11255-009-9658-2. [Epub ahead of print] PMID: 19866371

Diagnosis

Yuan Y, Zhang Z, Gao B, Peng J, Cui W, Song W, Xin Z, Guo Y
J Sex Med 2014 May;11(5):1201-7. Epub 2014 Mar 3 doi: 10.1111/jsm.12471. [Epub ahead of print] PMID: 24589237
Walsh TJ, Hotaling JM, Smith A, Saigal C, Wessells H
Int J Impot Res 2014 May-Jun;26(3):112-5. Epub 2013 Dec 19 doi: 10.1038/ijir.2013.46. [Epub ahead of print] PMID: 24352244
Roshanzamir S, Dabbaghmanesh A, Ashraf A
Burns 2014 Jun;40(4):624-9. Epub 2013 Dec 3 doi: 10.1016/j.burns.2013.08.033. [Epub ahead of print] PMID: 24309204
Spritzer SD, Zarkou S, Ireland SP, Carter JL, Goodman BP
Clin Auton Res 2013 Dec;23(6):333-8. Epub 2013 Aug 8 doi: 10.1007/s10286-013-0205-y. [Epub ahead of print] PMID: 23925719
Oguanobi NI, Onwubere BJ, Anisiuba BC, Ike SO, Ejim EC, Ibegbulam OG
Acta Cardiol 2012 Apr;67(2):169-75. PMID: 22641974

Therapy

Harte CB
J Sex Med 2014 May;11(5):1230-9. Epub 2014 Feb 27 doi: 10.1111/jsm.12486. [Epub ahead of print] PMID: 24576257
Walsh TJ, Hotaling JM, Smith A, Saigal C, Wessells H
Int J Impot Res 2014 May-Jun;26(3):112-5. Epub 2013 Dec 19 doi: 10.1038/ijir.2013.46. [Epub ahead of print] PMID: 24352244
Perez-Lloret S, Rey MV, Pavy-Le Traon A, Rascol O
Expert Opin Emerg Drugs 2013 Mar;18(1):39-53. Epub 2013 Feb 1 doi: 10.1517/14728214.2013.766168. [Epub ahead of print] PMID: 23373820
Harv Heart Lett 2012 Sep;23(1):5. PMID: 23101129
Andersson KE
Pharmacol Rev 2011 Dec;63(4):811-59. Epub 2011 Aug 31 doi: 10.1124/pr.111.004515. [Epub ahead of print] PMID: 21880989

Prognosis

Roshanzamir S, Dabbaghmanesh A, Ashraf A
Burns 2014 Jun;40(4):624-9. Epub 2013 Dec 3 doi: 10.1016/j.burns.2013.08.033. [Epub ahead of print] PMID: 24309204
Kneist W, Kauff DW, Rubenwolf P, Thomas C, Hampel C, Lang H
Dig Surg 2013;30(4-6):459-65. Epub 2014 Jan 29 doi: 10.1159/000357349. [Epub ahead of print] PMID: 24481247
Hida K, Hasegawa S, Kataoka Y, Nagayama S, Yoshimura K, Nomura A, Kawada K, Kawamura J, Kinjo Y, Sakai Y
Colorectal Dis 2013 Feb;15(2):244-51. doi: 10.1111/j.1463-1318.2012.03170.x. PMID: 22776077
Kim JY, Kim NK, Lee KY, Hur H, Min BS, Kim JH
Ann Surg Oncol 2012 Aug;19(8):2485-93. Epub 2012 Mar 21 doi: 10.1245/s10434-012-2262-1. [Epub ahead of print] PMID: 22434245
Dogru T, Kocak OM, Erberk-Ozen N, Basar M
Asian J Androl 2008 Jul;10(4):643-50. doi: 10.1111/j.1745-7262.2008.00383.x. PMID: 18478163

Clinical prediction guides

Umul M, Altay AB, Bademkiran F, Turna B, Semerci MB, Apaydin E, Cikili N
Turk J Med Sci 2014;44(4):681-6. PMID: 25551942
Yuan Y, Zhang Z, Gao B, Peng J, Cui W, Song W, Xin Z, Guo Y
J Sex Med 2014 May;11(5):1201-7. Epub 2014 Mar 3 doi: 10.1111/jsm.12471. [Epub ahead of print] PMID: 24589237
Harte CB
J Sex Med 2014 May;11(5):1230-9. Epub 2014 Feb 27 doi: 10.1111/jsm.12486. [Epub ahead of print] PMID: 24576257
Roshanzamir S, Dabbaghmanesh A, Ashraf A
Burns 2014 Jun;40(4):624-9. Epub 2013 Dec 3 doi: 10.1016/j.burns.2013.08.033. [Epub ahead of print] PMID: 24309204
Dogru MT, Basar MM
Int Urol Nephrol 2010 Sep;42(3):589-96. Epub 2009 Oct 29 doi: 10.1007/s11255-009-9658-2. [Epub ahead of print] PMID: 19866371

Recent systematic reviews

Denlinger CS, Carlson RW, Are M, Baker KS, Davis E, Edge SB, Friedman DL, Goldman M, Jones L, King A, Kvale E, Langbaum TS, Ligibel JA, McCabe MS, McVary KT, Melisko M, Montoya JG, Mooney K, Morgan MA, O'Connor T, Paskett ED, Raza M, Syrjala KL, Urba SG, Wakabayashi MT, Zee P, McMillian N, Freedman-Cass D; National comprehensive cancer network
J Natl Compr Canc Netw 2014 Mar 1;12(3):356-63. PMID: 24616541Free PMC Article
Wood LD, Neumiller JJ, Setter SM, Dobbins EK
Am J Geriatr Pharmacother 2010 Aug;8(4):294-315. doi: 10.1016/j.amjopharm.2010.08.002. PMID: 20869620
Kirby MG, Wagg A, Cardozo L, Chapple C, Castro-Diaz D, de Ridder D, Espuna-Pons M, Haab F, Kelleher C, Kölbl H, Milsom I, Van Kerrebroeck P, Vierhout M, Salvatore S, Tubaro A
Neurourol Urodyn 2010 Nov;29(8):1360-4. doi: 10.1002/nau.20892. PMID: 20589717
Jin LM
J Sex Med 2009 Mar;6 Suppl 3:302-10. doi: 10.1111/j.1743-6109.2008.01188.x. PMID: 19267853
Köhler TS, McVary KT
Eur Urol 2009 Jan;55(1):38-48. Epub 2008 Sep 4 doi: 10.1016/j.eururo.2008.08.062. [Epub ahead of print] PMID: 18783872

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