Display Settings:

Format

Send to:

Choose Destination
  • Quoted phrase not found.

Arteriosclerosis of small cerebral arteries

MedGen UID:
505723
Concept ID:
CN004374
Finding
 
HPO: HP:0004931

Definition

Arteriosclerosis (increased thickness, increased stiffness, loss of elasticity) of the small arteries of the brain. [from HPO]

Term Hierarchy

Conditions with this feature

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
MedGen UID:
325051
Concept ID:
C1838577
Disease or Syndrome
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by early-onset changes in the deep white matter of the brain observed on MRI and associated neurologic findings. The most frequent initial symptom is gait disturbance from spasticity beginning between ages 20 and 30 years. Twenty-three percent of affected individuals have stroke-like episodes before age 40 years. Mood changes (apathy and irritability), pseudobulbar palsy, and cognitive dysfunction begin between ages 20 and 50 years. The disease progresses slowly over the five to 20 years following the onset of neurologic symptoms. Scalp alopecia before age 30 years and acute mid- to lower-back pain (lumbago) with onset between ages ten and 40 years are characteristic.

Recent clinical studies

Etiology

Jeon SB, Kang DW, Kim JS, Kwon SU
Neurology 2014 Aug 19;83(8):695-701. Epub 2014 Jul 16 doi: 10.1212/WNL.0000000000000720. [Epub ahead of print] PMID: 25031284
Droste DW, Iliescu C, Vaillant M, Gantenbein M, De Bremaeker N, Lieunard C, Velez T, Meyer M, Guth T, Kuemmerle A, Chioti A
Cerebrovasc Dis 2014;37(5):368-75. Epub 2014 Jun 25 doi: 10.1159/000362535. [Epub ahead of print] PMID: 24970377
Karcher HS, Holzwarth R, Mueller HP, Ludolph AC, Huber R, Kassubek J, Pinkhardt EH
Cerebrovasc Dis 2013;35(4):341-8. Epub 2013 Apr 23 doi: 10.1159/000348703. [Epub ahead of print] PMID: 23615579
Ohnuki T, Takahashi W, Ohnuki Y, Kawada S, Takizawa S
Intern Med 2013;52(5):523-7. Epub 2013 Mar 1 PMID: 23448759
Park SY, An SA, Lee HB, Kim Y, Kim NK, Kim SH, Kim OJ, Oh SH
Thromb Res 2013 Jan;131(1):e12-6. Epub 2012 Dec 4 doi: 10.1016/j.thromres.2012.11.011. [Epub ahead of print] PMID: 23218488

Diagnosis

Jeon SB, Kang DW, Kim JS, Kwon SU
Neurology 2014 Aug 19;83(8):695-701. Epub 2014 Jul 16 doi: 10.1212/WNL.0000000000000720. [Epub ahead of print] PMID: 25031284
Karcher HS, Holzwarth R, Mueller HP, Ludolph AC, Huber R, Kassubek J, Pinkhardt EH
Cerebrovasc Dis 2013;35(4):341-8. Epub 2013 Apr 23 doi: 10.1159/000348703. [Epub ahead of print] PMID: 23615579
Ohnuki T, Takahashi W, Ohnuki Y, Kawada S, Takizawa S
Intern Med 2013;52(5):523-7. Epub 2013 Mar 1 PMID: 23448759
Park SY, An SA, Lee HB, Kim Y, Kim NK, Kim SH, Kim OJ, Oh SH
Thromb Res 2013 Jan;131(1):e12-6. Epub 2012 Dec 4 doi: 10.1016/j.thromres.2012.11.011. [Epub ahead of print] PMID: 23218488
Kim JS, Yoon Y
Int J Stroke 2013 Apr;8(3):197-203. Epub 2012 May 9 doi: 10.1111/j.1747-4949.2012.00816.x. [Epub ahead of print] PMID: 22568537

Therapy

Droste DW, Iliescu C, Vaillant M, Gantenbein M, De Bremaeker N, Lieunard C, Velez T, Meyer M, Guth T, Kuemmerle A, Chioti A
Cerebrovasc Dis 2014;37(5):368-75. Epub 2014 Jun 25 doi: 10.1159/000362535. [Epub ahead of print] PMID: 24970377
Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S
CNS Neurosci Ther 2014 Apr;20(4):364-7. Epub 2014 Jan 15 doi: 10.1111/cns.12224. [Epub ahead of print] PMID: 24423003
Zhang L, Huang Q, Zhang Y, Liu J, Hong B, Xu Y, Zhao W
AJNR Am J Neuroradiol 2012 Feb;33(2):343-7. Epub 2011 Dec 15 doi: 10.3174/ajnr.A2772. [Epub ahead of print] PMID: 22173759
Ochi N, Tabara Y, Igase M, Nagai T, Kido T, Miki T, Kohara K
Hypertens Res 2009 Apr;32(4):255-60. Epub 2009 Feb 27 doi: 10.1038/hr.2009.13. [Epub ahead of print] PMID: 19262493
Callahan AS 3rd, Berger BL
J Neuroimaging 1997 Oct;7(4):232-5. PMID: 9344006

Prognosis

Karcher HS, Holzwarth R, Mueller HP, Ludolph AC, Huber R, Kassubek J, Pinkhardt EH
Cerebrovasc Dis 2013;35(4):341-8. Epub 2013 Apr 23 doi: 10.1159/000348703. [Epub ahead of print] PMID: 23615579
Ohnuki T, Takahashi W, Ohnuki Y, Kawada S, Takizawa S
Intern Med 2013;52(5):523-7. Epub 2013 Mar 1 PMID: 23448759
Jeon SB, Chun S, Choi-Kwon S, Chi HS, Nah HW, Kwon SU, Kim WK, Kim JS
Atherosclerosis 2012 Aug;223(2):442-7. Epub 2012 Jun 8 doi: 10.1016/j.atherosclerosis.2012.04.013. [Epub ahead of print] PMID: 22727191
Fukutake T
J Stroke Cerebrovasc Dis 2011 Mar-Apr;20(2):85-93. Epub 2011 Jan 7 doi: 10.1016/j.jstrokecerebrovasdis.2010.11.008. [Epub ahead of print] PMID: 21215656
Lin WH, Hao Q, Rosengarten B, Leung WH, Wong KS
Eur J Neurol 2011 May;18(5):731-6. Epub 2010 Nov 30 doi: 10.1111/j.1468-1331.2010.03262.x. [Epub ahead of print] PMID: 21118330

Clinical prediction guides

Jeon SB, Kang DW, Kim JS, Kwon SU
Neurology 2014 Aug 19;83(8):695-701. Epub 2014 Jul 16 doi: 10.1212/WNL.0000000000000720. [Epub ahead of print] PMID: 25031284
Karcher HS, Holzwarth R, Mueller HP, Ludolph AC, Huber R, Kassubek J, Pinkhardt EH
Cerebrovasc Dis 2013;35(4):341-8. Epub 2013 Apr 23 doi: 10.1159/000348703. [Epub ahead of print] PMID: 23615579
Ohnuki T, Takahashi W, Ohnuki Y, Kawada S, Takizawa S
Intern Med 2013;52(5):523-7. Epub 2013 Mar 1 PMID: 23448759
Jeon SB, Chun S, Choi-Kwon S, Chi HS, Nah HW, Kwon SU, Kim WK, Kim JS
Atherosclerosis 2012 Aug;223(2):442-7. Epub 2012 Jun 8 doi: 10.1016/j.atherosclerosis.2012.04.013. [Epub ahead of print] PMID: 22727191
Fukutake T
J Stroke Cerebrovasc Dis 2011 Mar-Apr;20(2):85-93. Epub 2011 Jan 7 doi: 10.1016/j.jstrokecerebrovasdis.2010.11.008. [Epub ahead of print] PMID: 21215656

Recent systematic reviews

Vernooij JW, Kaasjager HA, van der Graaf Y, Wierdsma J, Grandjean HM, Hovens MM, de Wit GA, Visseren FL; SMARTStudy Group
BMJ 2012 Jun 12;344:e3750. PMID: 22692651Free PMC Article

Supplemental Content

Table of contents

    Consumer resources

    Outreach and support

    Clinical Trials

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...