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Musical perfect pitch(AP)

MedGen UID:
320397
Concept ID:
C1834650
Finding
Synonyms: ABSOLUTE PITCH
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
 
OMIM: 159300

Definition

Perfect pitch, or absolute pitch (AP), is defined as the ability immediately and effortlessly to name a note or collection of notes when they are sounded. Often, persons with perfect pitch possess a memory capacity whereby they can remember the pitch of a note and the configuration of a group or series of notes after a significant interval of time has elapsed. These recognitive and memory talents involve a potential capacity for performing these functions together with a practice factor which is necessary for the maintenance of the skills at the highest level (summary by Profita and Bidder, 1988). Absolute pitch likely results from a combination of environmental and genetic factors (Theusch et al., 2009). [from OMIM]

Clinical features

Abnormality of the ear
MedGen UID:
427827
Concept ID:
CN000560
Finding
An abnormality of the `ear` (FMA:52780).
Specific learning disability
MedGen UID:
504802
Concept ID:
CN001216
Finding
Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence.

Recent clinical studies

Etiology

Dohn A, Garza-Villarreal EA, Heaton P, Vuust P
PLoS One 2012;7(5):e37961. Epub 2012 May 30 doi: 10.1371/journal.pone.0037961. PMID: 22666425Free PMC Article
Wang W, Zhou N, Xu L
Int J Audiol 2011 Apr;50(4):270-8. Epub 2010 Dec 29 doi: 10.3109/14992027.2010.542490. [Epub ahead of print] PMID: 21190394
Zatorre RJ
Cortex 1989 Dec;25(4):567-80. PMID: 2612176

Diagnosis

Chubb C, Dickson CA, Dean T, Fagan C, Mann DS, Wright CE, Guan M, Silva AE, Gregersen PK, Kowalsky E
J Acoust Soc Am 2013 Oct;134(4):3067-78. doi: 10.1121/1.4816546. PMID: 24116441
Dohn A, Garza-Villarreal EA, Heaton P, Vuust P
PLoS One 2012;7(5):e37961. Epub 2012 May 30 doi: 10.1371/journal.pone.0037961. PMID: 22666425Free PMC Article
Thompson WF, Peter V, Olsen KN, Stevens CJ
Q J Exp Psychol (Hove) 2012;65(10):2054-72. Epub 2012 May 31 doi: 10.1080/17470218.2012.678369. [Epub ahead of print] PMID: 22650967
Young RL, Nettelbeck T
J Autism Dev Disord 1995 Jun;25(3):231-48. PMID: 7559290

Therapy

Kung CC, Hsieh TH, Liou JY, Lin KJ, Shaw FZ, Liang SF
Clin Neurophysiol 2014 May;125(5):971-8. Epub 2013 Oct 30 doi: 10.1016/j.clinph.2013.10.016. [Epub ahead of print] PMID: 24252396
Chubb C, Dickson CA, Dean T, Fagan C, Mann DS, Wright CE, Guan M, Silva AE, Gregersen PK, Kowalsky E
J Acoust Soc Am 2013 Oct;134(4):3067-78. doi: 10.1121/1.4816546. PMID: 24116441
Itoh K, Suwazono S, Nakada T
Neuroreport 2003 Dec 19;14(18):2303-6. doi: 10.1097/01.wnr.0000099989.54721.75. PMID: 14663180
Smith JD, Nelson DG, Grohskopf LA, Appleton T
Cognition 1994 Jul;52(1):23-54. PMID: 7924198
Zatorre RJ, Beckett C
Mem Cognit 1989 Sep;17(5):582-9. PMID: 2796743

Prognosis

Chubb C, Dickson CA, Dean T, Fagan C, Mann DS, Wright CE, Guan M, Silva AE, Gregersen PK, Kowalsky E
J Acoust Soc Am 2013 Oct;134(4):3067-78. doi: 10.1121/1.4816546. PMID: 24116441
Hughes JR
Adv Exp Med Biol 2012;724:332-43. doi: 10.1007/978-1-4614-0653-2_25. PMID: 22411254
Ross DA, Gore JC, Marks LE
Epilepsy Behav 2005 Dec;7(4):578-601. Epub 2005 Aug 15 doi: 10.1016/j.yebeh.2005.05.019. [Epub ahead of print] PMID: 16103017
Zatorre RJ
Cortex 1989 Dec;25(4):567-80. PMID: 2612176

Clinical prediction guides

Dohn A, Garza-Villarreal EA, Heaton P, Vuust P
PLoS One 2012;7(5):e37961. Epub 2012 May 30 doi: 10.1371/journal.pone.0037961. PMID: 22666425Free PMC Article
Hughes JR
Epilepsy Behav 2010 Feb;17(2):147-52. Epub 2010 Jan 13 doi: 10.1016/j.yebeh.2009.12.014. [Epub ahead of print] PMID: 20075011
Ross DA, Gore JC, Marks LE
Epilepsy Behav 2005 Dec;7(4):578-601. Epub 2005 Aug 15 doi: 10.1016/j.yebeh.2005.05.019. [Epub ahead of print] PMID: 16103017
Kong YY, Cruz R, Jones JA, Zeng FG
Ear Hear 2004 Apr;25(2):173-85. PMID: 15064662

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