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Novelty seeking personality trait

MedGen UID:
400998
Concept ID:
C1866430
Finding
Synonyms: NOVELTY SEEKING PERSONALITY TRAIT
 
Gene: DRD4
Cytogenetic location: 11p15.5
OMIM®: 601696

Definition

Human personality traits that can be reliably measured by rating scales show a considerable heritable component. One such instrument is the tridimensional personality questionnaire (TPQ), which was designed by Cloninger et al. (1993) to measure 4 distinct domains of temperament--novelty seeking, harm avoidance, reward dependence, and persistence--that are hypothesized to be based on distinct neurochemical and genetic substrates. Risk-taking is a characteristic of behaviors that occur under conditions of uncertainty and involves a tradeoff between beneficial versus detrimental outcomes, perceived or real. Risk-taking may or may not involve conscious evaluation of the probability and magnitude of possible outcomes (Anokhin et al., 2009). See also harm avoidance (see 607834) and pathologic gambling (606349), which may be related. [from OMIM]

Clinical features

Abnormality of the nervous system
MedGen UID:
428224
Concept ID:
CN000664
Finding
An abnormality of the nervous system.

Recent clinical studies

Etiology

Krebs RM, Schott BH, Düzel E
Biol Psychiatry 2009 Jan 15;65(2):103-10. Epub 2008 Oct 2 doi: 10.1016/j.biopsych.2008.08.019. [Epub ahead of print] PMID: 18835480
Boileau I, Dagher A, Leyton M, Gunn RN, Baker GB, Diksic M, Benkelfat C
Arch Gen Psychiatry 2006 Dec;63(12):1386-95. doi: 10.1001/archpsyc.63.12.1386. PMID: 17146013

Diagnosis

Szoke M, Sasvari-Szekely M, Barta C, Guttman A
Electrophoresis 1999 Mar;20(3):497-501. doi: 10.1002/(SICI)1522-2683(19990301)20:3<497::AID-ELPS497>3.0.CO;2-S. PMID: 10217162

Therapy

Boileau I, Dagher A, Leyton M, Gunn RN, Baker GB, Diksic M, Benkelfat C
Arch Gen Psychiatry 2006 Dec;63(12):1386-95. doi: 10.1001/archpsyc.63.12.1386. PMID: 17146013

Prognosis

Krebs RM, Schott BH, Düzel E
Biol Psychiatry 2009 Jan 15;65(2):103-10. Epub 2008 Oct 2 doi: 10.1016/j.biopsych.2008.08.019. [Epub ahead of print] PMID: 18835480
Boileau I, Dagher A, Leyton M, Gunn RN, Baker GB, Diksic M, Benkelfat C
Arch Gen Psychiatry 2006 Dec;63(12):1386-95. doi: 10.1001/archpsyc.63.12.1386. PMID: 17146013

Clinical prediction guides

Krebs RM, Schott BH, Düzel E
Biol Psychiatry 2009 Jan 15;65(2):103-10. Epub 2008 Oct 2 doi: 10.1016/j.biopsych.2008.08.019. [Epub ahead of print] PMID: 18835480
Boileau I, Dagher A, Leyton M, Gunn RN, Baker GB, Diksic M, Benkelfat C
Arch Gen Psychiatry 2006 Dec;63(12):1386-95. doi: 10.1001/archpsyc.63.12.1386. PMID: 17146013
Tsai SJ, Hong CJ, Yu YW, Chen TJ
Neuropsychobiology 2004;50(2):153-6. doi: 10.1159/000079107. PMID: 15292670
Okuyama Y, Ishiguro H, Nankai M, Shibuya H, Watanabe A, Arinami T
Mol Psychiatry 2000 Jan;5(1):64-9. PMID: 10673770

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