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Myxoid liposarcoma

MedGen UID:
104903
Concept ID:
C0206634
Neoplastic Process
Synonyms: Liposarcoma, Myxoid; Liposarcomas, Myxoid; Myxoid Liposarcoma; Myxoid Liposarcomas
Modes of inheritance:
Somatic mutation
MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
An alteration in DNA that occurs after conception. Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children. These alterations can (but do not always) cause cancer or other diseases.
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Describes a disorder that is not inherited.
SNOMED CT: Myxoid liposarcoma (404069006); Myxoid liposarcoma (27849002); Myxoliposarcoma (27849002)
 
Gene: DDIT3
Cytogenetic location: 12q13.3
OMIM®: 613488
Orphanet: ORPHA99967

Definition

Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by Dei Tos, 2000). [from OMIM]

Clinical features

Sarcoma
MedGen UID:
506452
Concept ID:
CN117138
Finding
The presence of a sarcoma.
Neoplasm of the lung
MedGen UID:
506475
Concept ID:
CN117419
Finding
Tumor of the lung.
Myxoid liposarcoma
MedGen UID:
506720
Concept ID:
CN168788
Finding
A liposarcoma that contains myxomatous tissue.
Abnormality of the urinary system
MedGen UID:
427792
Concept ID:
CN000079
Finding
An abnormality of the urinary system.
Abdominal pain
MedGen UID:
505060
Concept ID:
CN001834
Finding
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Abnormality of the intestine
MedGen UID:
427914
Concept ID:
CN002033
Finding
An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine.
Abnormality of the skin
MedGen UID:
504656
Concept ID:
CN000890
Finding
An abnormality of the skin.
Neoplasm of the lung
MedGen UID:
506475
Concept ID:
CN117419
Finding
Tumor of the lung.
Myxoid liposarcoma
MedGen UID:
506720
Concept ID:
CN168788
Finding
A liposarcoma that contains myxomatous tissue.

Term Hierarchy

Recent clinical studies

Etiology

Löwenthal D, Zeile M, Niederhagen M, Fehlberg S, Schnapauff D, Pink D, Tunn PU, Reichardt P, Hamm B, Dudeck O
Acta Radiol 2014 Oct;55(8):952-60. Epub 2013 Oct 11 doi: 10.1177/0284185113508114. [Epub ahead of print] PMID: 24123962
Dogan U, Zamani A, Gormus N, Paksoy Y, Avunduk MC, Demirbas S
Heart Surg Forum 2011 Aug;14(4):E261-3. doi: 10.1532/HSF98.20111021. PMID: 21859649
Pattani KM, Lian TS
Ear Nose Throat J 2010 Sep;89(9):466-7. PMID: 20859874
Kato S, Kawahara N, Murakami H, Demura S, Shirai T, Tsuchiya H, Tomita K
Orthopedics 2010 Jun 9;33(6):446. doi: 10.3928/01477447-20100429-33. PMID: 20806757
Nishida Y, Tsukushi S, Nakashima H, Ishiguro N
Clin Orthop Relat Res 2010 Nov;468(11):3041-6. doi: 10.1007/s11999-010-1396-3. PMID: 20499293Free PMC Article

Diagnosis

Fan Z, Tian XF, Tang SX, Zhang YY, Pan JY, Wang S
Medicine (Baltimore) 2014 Dec;93(28):e239. doi: 10.1097/MD.0000000000000239. PMID: 25526446
Yokouchi M, Nagano S, Kijima Y, Yoshioka T, Tanimoto A, Natsugoe S, Komiya S
BMC Cancer 2014 Jul 4;14:482. doi: 10.1186/1471-2407-14-482. [Epub ahead of print] PMID: 24994066Free PMC Article
Löwenthal D, Zeile M, Niederhagen M, Fehlberg S, Schnapauff D, Pink D, Tunn PU, Reichardt P, Hamm B, Dudeck O
Acta Radiol 2014 Oct;55(8):952-60. Epub 2013 Oct 11 doi: 10.1177/0284185113508114. [Epub ahead of print] PMID: 24123962
Abete L, Simonato A, Toncini C, Carmignani G, Derchi LE
J Clin Ultrasound 2014 Feb;42(2):96-9. Epub 2013 Jul 17 doi: 10.1002/jcu.22068. [Epub ahead of print] PMID: 23861011
Saito T, Ryu M, Fukumura Y, Asahina M, Arakawa A, Nakai K, Miura H, Saito M, Yao T
Int J Clin Exp Pathol 2013;6(7):1432-6. Epub 2013 Jun 15 PMID: 23826427Free PMC Article

Therapy

Uboldi S, Calura E, Beltrame L, Fuso Nerini I, Marchini S, Cavalieri D, Erba E, Chiorino G, Ostano P, D'Angelo D, D'Incalci M, Romualdi C
PLoS One 2012;7(4):e35423. Epub 2012 Apr 16 doi: 10.1371/journal.pone.0035423. PMID: 22523595Free PMC Article
Gronchi A, Bui BN, Bonvalot S, Pilotti S, Ferrari S, Hohenberger P, Hohl RJ, Demetri GD, Le Cesne A, Lardelli P, Pérez I, Nieto A, Tercero JC, Alfaro V, Tamborini E, Blay JY
Ann Oncol 2012 Mar;23(3):771-6. Epub 2011 Jun 3 doi: 10.1093/annonc/mdr265. [Epub ahead of print] PMID: 21642514
Dogan U, Zamani A, Gormus N, Paksoy Y, Avunduk MC, Demirbas S
Heart Surg Forum 2011 Aug;14(4):E261-3. doi: 10.1532/HSF98.20111021. PMID: 21859649
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovée JV
Mol Cancer 2010 Sep 23;9:257. doi: 10.1186/1476-4598-9-257. [Epub ahead of print] PMID: 20863376Free PMC Article
Nishida Y, Tsukushi S, Nakashima H, Ishiguro N
Clin Orthop Relat Res 2010 Nov;468(11):3041-6. doi: 10.1007/s11999-010-1396-3. PMID: 20499293Free PMC Article

Prognosis

Nabeshima A, Matsumoto Y, Fukushi J, Iura K, Matsunobu T, Endo M, Fujiwara T, Iida K, Fujiwara Y, Hatano M, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y
Br J Cancer 2015 Feb 3;112(3):547-55. Epub 2015 Jan 6 doi: 10.1038/bjc.2014.637. [Epub ahead of print] PMID: 25562433
Löwenthal D, Zeile M, Niederhagen M, Fehlberg S, Schnapauff D, Pink D, Tunn PU, Reichardt P, Hamm B, Dudeck O
Acta Radiol 2014 Oct;55(8):952-60. Epub 2013 Oct 11 doi: 10.1177/0284185113508114. [Epub ahead of print] PMID: 24123962
Saito T, Ryu M, Fukumura Y, Asahina M, Arakawa A, Nakai K, Miura H, Saito M, Yao T
Int J Clin Exp Pathol 2013;6(7):1432-6. Epub 2013 Jun 15 PMID: 23826427Free PMC Article
Sakamoto A, Fukutoku Y, Matsumoto Y, Harimaya K, Oda Y, Iwamoto Y
World J Surg Oncol 2012 Oct 9;10:214. doi: 10.1186/1477-7819-10-214. [Epub ahead of print] PMID: 23046828Free PMC Article
Seo SW, Kwon JW, Jang SW, Jang SP, Park YS
Orthopedics 2011 Nov 9;34(11):e748-54. doi: 10.3928/01477447-20110922-15. PMID: 22049957

Clinical prediction guides

Nabeshima A, Matsumoto Y, Fukushi J, Iura K, Matsunobu T, Endo M, Fujiwara T, Iida K, Fujiwara Y, Hatano M, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y
Br J Cancer 2015 Feb 3;112(3):547-55. Epub 2015 Jan 6 doi: 10.1038/bjc.2014.637. [Epub ahead of print] PMID: 25562433
Yokouchi M, Nagano S, Kijima Y, Yoshioka T, Tanimoto A, Natsugoe S, Komiya S
BMC Cancer 2014 Jul 4;14:482. doi: 10.1186/1471-2407-14-482. [Epub ahead of print] PMID: 24994066Free PMC Article
Löwenthal D, Zeile M, Niederhagen M, Fehlberg S, Schnapauff D, Pink D, Tunn PU, Reichardt P, Hamm B, Dudeck O
Acta Radiol 2014 Oct;55(8):952-60. Epub 2013 Oct 11 doi: 10.1177/0284185113508114. [Epub ahead of print] PMID: 24123962
Saito T, Ryu M, Fukumura Y, Asahina M, Arakawa A, Nakai K, Miura H, Saito M, Yao T
Int J Clin Exp Pathol 2013;6(7):1432-6. Epub 2013 Jun 15 PMID: 23826427Free PMC Article
Seo SW, Kwon JW, Jang SW, Jang SP, Park YS
Orthopedics 2011 Nov 9;34(11):e748-54. doi: 10.3928/01477447-20110922-15. PMID: 22049957

Recent systematic reviews

Jeng CJ, Tzen CY, Huang WC, Yang YC, Shen J, Tzeng CR
Int J Gynecol Cancer 2005 Nov-Dec;15(6):1235-8. doi: 10.1111/j.1525-1438.2005.00180.x. PMID: 16343222
Miller GG, Yanchar NL, Magee JF, Blair GK
Can J Surg 1998 Dec;41(6):455-8. PMID: 9854536Free PMC Article

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