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Migraine(MA)

MedGen UID:
57451
Concept ID:
C0149931
Disease or Syndrome
Synonyms: Migraine Disorders; MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: Migraine (37796009)
 
Genes: TNF; ESR1; EDNRA
Cytogenetic locations: 6p21.33; 6q25.1-25.2
OMIM: 157300

Definition

Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; 607498), 14q21.2-q22.3 (MGR4; 607501), 19p13 (MGR5; 607508), 1q31 (MGR6; 607516), 15q11-q13 (MGR7; 609179), 5q21 (with or without aura, MGR8, 609570; with aura, MGR9, 609670), 17p13 (MGR10; 610208), 18q12 (MGR11; 610209), 10q22-q23 (MGR12; 611706), and the X chromosome (MGR2; 300125). Mutation in the KCNK18 gene (613655) on chromosome 10q25 causes migraine with aura (MGR13; 613656). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see 141500), is caused by mutation in the CACNA1A gene (601011) on chromosome 19p13 (FHM1; 141500), by mutation in the ATP1A2 gene (182340) on chromosome 1q21 (FHM2; 602481), or by mutation in the SCN1A gene (182389) on chromosome 2q24 (FHM3; 609634). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see 607516). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; 133430.0005) and a polymorphism in the TNF gene (191160.0004) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; 131243.0001) may confer resistance to migraine. [from OMIM]

Clinical features

Photophobia
MedGen UID:
504524
Concept ID:
CN000575
Finding
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Photophobia
MedGen UID:
504524
Concept ID:
CN000575
Finding
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Migraine with aura
MedGen UID:
505086
Concept ID:
CN001879
Finding
A type of `migraine` (HP:0002076) in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
Migraine without aura
MedGen UID:
505090
Concept ID:
CN001884
Finding
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.
Phonophobia
MedGen UID:
505146
Concept ID:
CN001979
Finding
An abnormally heightened sensitivity to loud sounds.

Recent clinical studies

Etiology

Monteith T, Gardener H, Rundek T, Dong C, Yoshita M, Elkind MS, DeCarli C, Sacco RL, Wright CB
Stroke 2014 Jun;45(6):1830-2. Epub 2014 May 15 doi: 10.1161/STROKEAHA.114.005447. [Epub ahead of print] PMID: 24876263Free PMC Article
Russo A, Marcelli V, Esposito F, Corvino V, Marcuccio L, Giannone A, Conforti R, Marciano E, Tedeschi G, Tessitore A
Neurology 2014 Jun 10;82(23):2120-6. Epub 2014 May 9 doi: 10.1212/WNL.0000000000000496. [Epub ahead of print] PMID: 24814847
Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. [Epub ahead of print] PMID: 24645145
Lip PZ, Lip GY
Am J Med 2014 May;127(5):411-20. Epub 2013 Dec 17 doi: 10.1016/j.amjmed.2013.12.006. [Epub ahead of print] PMID: 24355354
Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P
Pain 2013 Dec;154(12):2691-9. Epub 2013 Aug 2 doi: 10.1016/j.pain.2013.07.050. [Epub ahead of print] PMID: 23911697

Diagnosis

Saunders EF, Nazir R, Kamali M, Ryan KA, Evans S, Langenecker S, Gelenberg AJ, McInnis MG
J Clin Psychiatry 2014 May;75(5):512-9. doi: 10.4088/JCP.13m08623. PMID: 24816075
Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. [Epub ahead of print] PMID: 24645145
Dadaci Z, Doganay F, Oncel Acir N, Aydin HD, Borazan M
Br J Ophthalmol 2014 Jul;98(7):972-5. Epub 2014 Feb 26 doi: 10.1136/bjophthalmol-2013-304711. [Epub ahead of print] PMID: 24574436
Sharon JD, Hullar TE
Laryngoscope 2014 Apr;124(4):969-73. Epub 2014 Jan 15 doi: 10.1002/lary.24285. [Epub ahead of print] PMID: 23818082Free PMC Article
Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P
Pain 2013 Dec;154(12):2691-9. Epub 2013 Aug 2 doi: 10.1016/j.pain.2013.07.050. [Epub ahead of print] PMID: 23911697

Therapy

Monteith T, Gardener H, Rundek T, Dong C, Yoshita M, Elkind MS, DeCarli C, Sacco RL, Wright CB
Stroke 2014 Jun;45(6):1830-2. Epub 2014 May 15 doi: 10.1161/STROKEAHA.114.005447. [Epub ahead of print] PMID: 24876263Free PMC Article
Tibber MS, Kelly MG, Jansari A, Dakin SC, Shepherd AJ
Invest Ophthalmol Vis Sci 2014 Apr 17;55(4):2539-46. doi: 10.1167/iovs.14-13877. PMID: 24677099Free PMC Article
Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. [Epub ahead of print] PMID: 24645145
Dadaci Z, Doganay F, Oncel Acir N, Aydin HD, Borazan M
Br J Ophthalmol 2014 Jul;98(7):972-5. Epub 2014 Feb 26 doi: 10.1136/bjophthalmol-2013-304711. [Epub ahead of print] PMID: 24574436
Lip PZ, Lip GY
Am J Med 2014 May;127(5):411-20. Epub 2013 Dec 17 doi: 10.1016/j.amjmed.2013.12.006. [Epub ahead of print] PMID: 24355354

Prognosis

Cady R, O'Carroll P, Dexter K, Freitag F, Shade CL
Headache 2014 Jan;54(1):67-79. Epub 2013 Sep 10 doi: 10.1111/head.12211. [Epub ahead of print] PMID: 24021029
Nguyen BN, Vingrys AJ, McKendrick AM
Cephalalgia 2014 Jan;34(1):42-57. Epub 2013 Aug 22 doi: 10.1177/0333102413498939. [Epub ahead of print] PMID: 23969723
Silva-Néto RP, Peres MF, Valença MM
Cephalalgia 2014 Jan;34(1):14-21. Epub 2013 Jul 5 doi: 10.1177/0333102413495969. [Epub ahead of print] PMID: 23832131
Liu J, Lan L, Li G, Yan X, Nan J, Xiong S, Yin Q, von Deneen KM, Gong Q, Liang F, Qin W, Tian J
J Pain 2013 Dec;14(12):1703-8. doi: 10.1016/j.jpain.2013.08.013. PMID: 24290450
Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P
Pain 2013 Dec;154(12):2691-9. Epub 2013 Aug 2 doi: 10.1016/j.pain.2013.07.050. [Epub ahead of print] PMID: 23911697

Clinical prediction guides

Monteith T, Gardener H, Rundek T, Dong C, Yoshita M, Elkind MS, DeCarli C, Sacco RL, Wright CB
Stroke 2014 Jun;45(6):1830-2. Epub 2014 May 15 doi: 10.1161/STROKEAHA.114.005447. [Epub ahead of print] PMID: 24876263Free PMC Article
Dadaci Z, Doganay F, Oncel Acir N, Aydin HD, Borazan M
Br J Ophthalmol 2014 Jul;98(7):972-5. Epub 2014 Feb 26 doi: 10.1136/bjophthalmol-2013-304711. [Epub ahead of print] PMID: 24574436
Amin FM, Hougaard A, Schytz HW, Asghar MS, Lundholm E, Parvaiz AI, de Koning PJ, Andersen MR, Larsson HB, Fahrenkrug J, Olesen J, Ashina M
Brain 2014 Mar;137(Pt 3):779-94. Epub 2014 Feb 5 doi: 10.1093/brain/awt369. [Epub ahead of print] PMID: 24501094
Lip PZ, Lip GY
Am J Med 2014 May;127(5):411-20. Epub 2013 Dec 17 doi: 10.1016/j.amjmed.2013.12.006. [Epub ahead of print] PMID: 24355354
Sharon JD, Hullar TE
Laryngoscope 2014 Apr;124(4):969-73. Epub 2014 Jan 15 doi: 10.1002/lary.24285. [Epub ahead of print] PMID: 23818082Free PMC Article

Recent systematic reviews

Schankin CJ, Maniyar FH, Digre KB, Goadsby PJ
Brain 2014 May;137(Pt 5):1419-28. Epub 2014 Mar 18 doi: 10.1093/brain/awu050. [Epub ahead of print] PMID: 24645145
Lip PZ, Lip GY
Am J Med 2014 May;127(5):411-20. Epub 2013 Dec 17 doi: 10.1016/j.amjmed.2013.12.006. [Epub ahead of print] PMID: 24355354
Sacco S, Ornello R, Ripa P, Pistoia F, Carolei A
Stroke 2013 Nov;44(11):3032-8. Epub 2013 Oct 1 doi: 10.1161/STROKEAHA.113.002465. [Epub ahead of print] PMID: 24085027
Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group
Can J Neurol Sci 2013 Sep;40(5 Suppl 3):S1-S80. PMID: 23968886
Lee M, Lineberry K, Reed D, Guyuron B
J Plast Reconstr Aesthet Surg 2013 Oct;66(10):1335-9. Epub 2013 Jun 2 doi: 10.1016/j.bjps.2013.05.023. [Epub ahead of print] PMID: 23735289

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