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Trigeminal neuralgia

MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
Synonyms: Tic Douloureux
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: TN - Trigeminal neuralgia (31681005); Trigeminal neuralgia (31681005); Tic douloureux (31681005); Trifacial neuralgia (31681005); Fothergill's neuralgia (31681005)
 
OMIM®: 190400
Orphanet: ORPHA221091

Definition

Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no single test to diagnose TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke.  [from MedlinePlus]

Clinical features

Trigeminal neuralgia
MedGen UID:
506510
Concept ID:
CN117553
Finding
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGTrigeminal neuralgia

Recent clinical studies

Etiology

Bakker NA, Van Dijk JM, Immenga S, Wagemakers M, Metzemaekers JD
J Neurosurg 2014 Oct;121(4):936-9. Epub 2014 Aug 1 doi: 10.3171/2014.7.JNS132667. [Epub ahead of print] PMID: 25084464
Leal PR, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M
J Neurosurg 2014 Jun;120(6):1484-95. Epub 2014 Apr 18 doi: 10.3171/2014.2.JNS131288. [Epub ahead of print] PMID: 24745706
Chen MJ, Zhang WJ, Guo ZL, Zhang WH, Chai Y, Li YW
J Neurol Sci 2014 Mar 15;338(1-2):43-5. Epub 2013 Dec 11 doi: 10.1016/j.jns.2013.12.013. [Epub ahead of print] PMID: 24387898
Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD
Stereotact Funct Neurosurg 2014;92(1):53-8. Epub 2013 Nov 8 doi: 10.1159/000354815. [Epub ahead of print] PMID: 24217153
Chen GQ, Wang XS, Wang L, Zheng JP
Neurol Sci 2014 Jan;35(1):61-6. Epub 2013 Aug 21 doi: 10.1007/s10072-013-1518-2. [Epub ahead of print] PMID: 23963805Free PMC Article

Diagnosis

Amagasaki K, Abe S, Watanabe S, Naemura K, Nakaguchi H
J Neurosurg 2014 Oct;121(4):940-3. Epub 2014 Jul 11 doi: 10.3171/2014.6.JNS132292. [Epub ahead of print] PMID: 25014438
Wright E, Evans J
Cranio 2014 Jul;32(3):193-8. Epub 2014 Jan 24 doi: 10.1179/0886963413Z.00000000023. [Epub ahead of print] PMID: 25000161
Leal PR, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M
J Neurosurg 2014 Jun;120(6):1484-95. Epub 2014 Apr 18 doi: 10.3171/2014.2.JNS131288. [Epub ahead of print] PMID: 24745706
Lu X, Qin X, Ni L, Chen J, Xu F
BMJ Case Rep 2013 Nov 27;2013 doi: 10.1136/bcr-2013-010984. PMID: 24285803
El-Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Abdel Hakeem M N, Badry R, Kandil MR
Clin Neurol Neurosurg 2013 Sep;115(9):1792-4. Epub 2013 May 18 doi: 10.1016/j.clineuro.2013.04.014. [Epub ahead of print] PMID: 23692870

Therapy

Bakker NA, Van Dijk JM, Immenga S, Wagemakers M, Metzemaekers JD
J Neurosurg 2014 Oct;121(4):936-9. Epub 2014 Aug 1 doi: 10.3171/2014.7.JNS132667. [Epub ahead of print] PMID: 25084464
Chen MJ, Zhang WJ, Guo ZL, Zhang WH, Chai Y, Li YW
J Neurol Sci 2014 Mar 15;338(1-2):43-5. Epub 2013 Dec 11 doi: 10.1016/j.jns.2013.12.013. [Epub ahead of print] PMID: 24387898
Lu X, Qin X, Ni L, Chen J, Xu F
BMJ Case Rep 2013 Nov 27;2013 doi: 10.1136/bcr-2013-010984. PMID: 24285803
Zakrzewska JM, Palmer J, Ettlin DA, Obermann M, Giblin GM, Morisset V, Tate S, Gunn K
Trials 2013 Nov 23;14:402. doi: 10.1186/1745-6215-14-402. [Epub ahead of print] PMID: 24267010Free PMC Article
Chan MD, Shaw EG, Tatter SB
Neurosurg Clin N Am 2013 Oct;24(4):613-21. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.001. [Epub ahead of print] PMID: 24093579

Prognosis

Amagasaki K, Abe S, Watanabe S, Naemura K, Nakaguchi H
J Neurosurg 2014 Oct;121(4):940-3. Epub 2014 Jul 11 doi: 10.3171/2014.6.JNS132292. [Epub ahead of print] PMID: 25014438
Leal PR, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M
J Neurosurg 2014 Jun;120(6):1484-95. Epub 2014 Apr 18 doi: 10.3171/2014.2.JNS131288. [Epub ahead of print] PMID: 24745706
Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD
Stereotact Funct Neurosurg 2014;92(1):53-8. Epub 2013 Nov 8 doi: 10.1159/000354815. [Epub ahead of print] PMID: 24217153
Goodwin CR, Yang JX, Bettegowda C, Hwang B, James C, Biser A, Raza S, Bender M, Carson B, Lee JY, Lim M
Clin Neurol Neurosurg 2013 Dec;115(12):2454-6. Epub 2013 Sep 25 doi: 10.1016/j.clineuro.2013.09.009. [Epub ahead of print] PMID: 24161889
Chan MD, Shaw EG, Tatter SB
Neurosurg Clin N Am 2013 Oct;24(4):613-21. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.001. [Epub ahead of print] PMID: 24093579

Clinical prediction guides

Leal PR, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M
J Neurosurg 2014 Jun;120(6):1484-95. Epub 2014 Apr 18 doi: 10.3171/2014.2.JNS131288. [Epub ahead of print] PMID: 24745706
Weller M, Marshall K, Lovato JF, Bourland JD, deGuzman AF, Munley MT, Shaw EG, Tatter SB, Chan MD
Stereotact Funct Neurosurg 2014;92(1):53-8. Epub 2013 Nov 8 doi: 10.1159/000354815. [Epub ahead of print] PMID: 24217153
Chan MD, Shaw EG, Tatter SB
Neurosurg Clin N Am 2013 Oct;24(4):613-21. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.001. [Epub ahead of print] PMID: 24093579
El-Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Abdel Hakeem M N, Badry R, Kandil MR
Clin Neurol Neurosurg 2013 Sep;115(9):1792-4. Epub 2013 May 18 doi: 10.1016/j.clineuro.2013.04.014. [Epub ahead of print] PMID: 23692870
Shimizu M, Imai H, Kagoshima K, Umezawa E, Shimizu T, Yoshimoto Y
World Neurosurg 2013 Sep-Oct;80(3-4):378-85. Epub 2012 Sep 25 doi: 10.1016/j.wneu.2012.05.030. [Epub ahead of print] PMID: 23022639

Recent systematic reviews

Zhang J, Yang M, Zhou M, He L, Chen N, Zakrzewska JM
Cochrane Database Syst Rev 2013 Dec 3;12:CD004029. doi: 10.1002/14651858.CD004029.pub4. PMID: 24297506
Akram H, Mirza B, Kitchen N, Zakrzewska JM
Neurosurg Focus 2013 Sep;35(3):E3. doi: 10.3171/2013.6.FOCUS13213. PMID: 23991816
Hu Y, Guan X, Fan L, Li M, Liao Y, Nie Z, Jin L
J Headache Pain 2013 Aug 21;14:72. doi: 10.1186/1129-2377-14-72. [Epub ahead of print] PMID: 23964790Free PMC Article
Montano N, Papacci F, Cioni B, Di Bonaventura R, Meglio M
Clin Neurol Neurosurg 2013 May;115(5):567-72. Epub 2012 Jul 26 doi: 10.1016/j.clineuro.2012.07.011. [Epub ahead of print] PMID: 22840414
Bergenheim AT, Asplund P, Linderoth B
World Neurosurg 2013 Feb;79(2):359-68. Epub 2012 Apr 2 doi: 10.1016/j.wneu.2012.03.014. [Epub ahead of print] PMID: 22480980

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