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Trigeminal neuralgia

MedGen UID:
21683
Concept ID:
C0040997
Disease or Syndrome
Synonyms: Tic Douloureux
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
SNOMED CT: TN - Trigeminal neuralgia (31681005); Trigeminal neuralgia (31681005); Tic douloureux (31681005); Trifacial neuralgia (31681005); Fothergill's neuralgia (31681005)
 
OMIM: 190400

Definition

A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187) [from MeSH]

Clinical features

Trigeminal neuralgia
MedGen UID:
506510
Concept ID:
CN117553
Finding
A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGTrigeminal neuralgia

Recent clinical studies

Etiology

Setty P, Volkov AA, D'Andrea KP, Pieper DR
World Neurosurg 2014 Mar-Apr;81(3-4):603-8. Epub 2013 Oct 17 doi: 10.1016/j.wneu.2013.10.036. [Epub ahead of print] PMID: 24140999
Ariai MS, Mallory GW, Pollock BE
World Neurosurg 2014 Mar-Apr;81(3-4):599-603. Epub 2013 Sep 19 doi: 10.1016/j.wneu.2013.09.027. [Epub ahead of print] PMID: 24056218
Chen GQ, Wang XS, Wang L, Zheng JP
Neurol Sci 2014 Jan;35(1):61-6. Epub 2013 Aug 21 doi: 10.1007/s10072-013-1518-2. [Epub ahead of print] PMID: 23963805Free PMC Article
Zhang J, Yang M, Zhou M, He L, Chen N, Zakrzewska JM
Cochrane Database Syst Rev 2013 Dec 3;12:CD004029. doi: 10.1002/14651858.CD004029.pub4. PMID: 24297506
Goodwin CR, Yang JX, Bettegowda C, Hwang B, James C, Biser A, Raza S, Bender M, Carson B, Lee JY, Lim M
Clin Neurol Neurosurg 2013 Dec;115(12):2454-6. Epub 2013 Sep 25 doi: 10.1016/j.clineuro.2013.09.009. [Epub ahead of print] PMID: 24161889

Diagnosis

Wright E, Evans J
Cranio 2014 Jul;32(3):193-8. Epub 2014 Jan 24 doi: 10.1179/0886963413Z.00000000023. [Epub ahead of print] PMID: 25000161
Lee A, McCartney S, Burbidge C, Raslan AM, Burchiel KJ
J Neurosurg 2014 May;120(5):1048-54. Epub 2014 Feb 7 doi: 10.3171/2014.1.JNS131410. [Epub ahead of print] PMID: 24506241
Lu X, Qin X, Ni L, Chen J, Xu F
BMJ Case Rep 2013 Nov 27;2013 doi: 10.1136/bcr-2013-010984. PMID: 24285803
El-Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Abdel Hakeem M N, Badry R, Kandil MR
Clin Neurol Neurosurg 2013 Sep;115(9):1792-4. Epub 2013 May 18 doi: 10.1016/j.clineuro.2013.04.014. [Epub ahead of print] PMID: 23692870
Shimizu M, Imai H, Kagoshima K, Umezawa E, Shimizu T, Yoshimoto Y
World Neurosurg 2013 Sep-Oct;80(3-4):378-85. Epub 2012 Sep 25 doi: 10.1016/j.wneu.2012.05.030. [Epub ahead of print] PMID: 23022639

Therapy

Setty P, Volkov AA, D'Andrea KP, Pieper DR
World Neurosurg 2014 Mar-Apr;81(3-4):603-8. Epub 2013 Oct 17 doi: 10.1016/j.wneu.2013.10.036. [Epub ahead of print] PMID: 24140999
Ariai MS, Mallory GW, Pollock BE
World Neurosurg 2014 Mar-Apr;81(3-4):599-603. Epub 2013 Sep 19 doi: 10.1016/j.wneu.2013.09.027. [Epub ahead of print] PMID: 24056218
Zhang J, Yang M, Zhou M, He L, Chen N, Zakrzewska JM
Cochrane Database Syst Rev 2013 Dec 3;12:CD004029. doi: 10.1002/14651858.CD004029.pub4. PMID: 24297506
Lu X, Qin X, Ni L, Chen J, Xu F
BMJ Case Rep 2013 Nov 27;2013 doi: 10.1136/bcr-2013-010984. PMID: 24285803
Chan MD, Shaw EG, Tatter SB
Neurosurg Clin N Am 2013 Oct;24(4):613-21. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.001. [Epub ahead of print] PMID: 24093579

Prognosis

Xu Z, Schlesinger D, Moldovan K, Przybylowski C, Sun X, Lee CC, Yen CP, Sheehan J
J Neurosurg 2014 Mar;120(3):716-24. Epub 2013 Dec 6 doi: 10.3171/2013.10.JNS131596. [Epub ahead of print] PMID: 24313616
Goodwin CR, Yang JX, Bettegowda C, Hwang B, James C, Biser A, Raza S, Bender M, Carson B, Lee JY, Lim M
Clin Neurol Neurosurg 2013 Dec;115(12):2454-6. Epub 2013 Sep 25 doi: 10.1016/j.clineuro.2013.09.009. [Epub ahead of print] PMID: 24161889
Chan MD, Shaw EG, Tatter SB
Neurosurg Clin N Am 2013 Oct;24(4):613-21. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.001. [Epub ahead of print] PMID: 24093579
Akram H, Mirza B, Kitchen N, Zakrzewska JM
Neurosurg Focus 2013 Sep;35(3):E3. doi: 10.3171/2013.6.FOCUS13213. PMID: 23991816
Ma X, Sun X, Yao J, Ni S, Gong J, Wang J, Li X
Neurosurg Rev 2013 Oct;36(4):573-7; discussion 577-8. Epub 2013 May 5 doi: 10.1007/s10143-013-0468-8. [Epub ahead of print] PMID: 23645139

Clinical prediction guides

Setty P, Volkov AA, D'Andrea KP, Pieper DR
World Neurosurg 2014 Mar-Apr;81(3-4):603-8. Epub 2013 Oct 17 doi: 10.1016/j.wneu.2013.10.036. [Epub ahead of print] PMID: 24140999
Goodwin CR, Yang JX, Bettegowda C, Hwang B, James C, Biser A, Raza S, Bender M, Carson B, Lee JY, Lim M
Clin Neurol Neurosurg 2013 Dec;115(12):2454-6. Epub 2013 Sep 25 doi: 10.1016/j.clineuro.2013.09.009. [Epub ahead of print] PMID: 24161889
Chan MD, Shaw EG, Tatter SB
Neurosurg Clin N Am 2013 Oct;24(4):613-21. Epub 2013 Aug 2 doi: 10.1016/j.nec.2013.05.001. [Epub ahead of print] PMID: 24093579
El-Tallawy HN, Farghaly WM, Rageh TA, Shehata GA, Abdel Hakeem M N, Badry R, Kandil MR
Clin Neurol Neurosurg 2013 Sep;115(9):1792-4. Epub 2013 May 18 doi: 10.1016/j.clineuro.2013.04.014. [Epub ahead of print] PMID: 23692870
Shimizu M, Imai H, Kagoshima K, Umezawa E, Shimizu T, Yoshimoto Y
World Neurosurg 2013 Sep-Oct;80(3-4):378-85. Epub 2012 Sep 25 doi: 10.1016/j.wneu.2012.05.030. [Epub ahead of print] PMID: 23022639

Recent systematic reviews

Zhang J, Yang M, Zhou M, He L, Chen N, Zakrzewska JM
Cochrane Database Syst Rev 2013 Dec 3;12:CD004029. doi: 10.1002/14651858.CD004029.pub4. PMID: 24297506
Akram H, Mirza B, Kitchen N, Zakrzewska JM
Neurosurg Focus 2013 Sep;35(3):E3. doi: 10.3171/2013.6.FOCUS13213. PMID: 23991816
Montano N, Papacci F, Cioni B, Di Bonaventura R, Meglio M
Clin Neurol Neurosurg 2013 May;115(5):567-72. Epub 2012 Jul 26 doi: 10.1016/j.clineuro.2012.07.011. [Epub ahead of print] PMID: 22840414
Bergenheim AT, Asplund P, Linderoth B
World Neurosurg 2013 Feb;79(2):359-68. Epub 2012 Apr 2 doi: 10.1016/j.wneu.2012.03.014. [Epub ahead of print] PMID: 22480980
Wang QP, Bai M
CNS Drugs 2011 Oct 1;25(10):847-57. doi: 10.2165/11595590-000000000-00000. PMID: 21936587

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