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Antithrombin III(AT3)

MedGen UID:
1993
Concept ID:
C0003438
Pharmacologic Substance
Synonyms: Cofactor I, Heparin; Heparin Co Factor I; Heparin Co-Factor I; Heparin Cofactor I; Serpin C1
SNOMED CT: Antithrombin III product (109001008); Antithrombin III preparation (109001008); Heparin cofactor I (34086003); Antithrombin II (34086003); Antithrombin III (34086003)
 
OMIM: 107300

Definition

Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGAntithrombin III

Recent clinical studies

Etiology

Corder A, Held K, Oschman A
Pediatr Blood Cancer 2014 Jun;61(6):1063-7. Epub 2013 Dec 20 doi: 10.1002/pbc.24899. [Epub ahead of print] PMID: 24375987
Kumar A, Bhandari A, Sarde SJ, Goswami C
Biochem Biophys Res Commun 2013 Nov 1;440(4):714-24. Epub 2013 Oct 9 doi: 10.1016/j.bbrc.2013.09.134. [Epub ahead of print] PMID: 24121110
Perry R, Stein J, Young G, Ramanathan R, Seri I, Klee L, Friedlich P
J Pediatr Surg 2013 Sep;48(9):1837-42. doi: 10.1016/j.jpedsurg.2012.11.037. PMID: 24074654
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667

Diagnosis

Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Kanbak M, Oc B, Salman MA, Ocal T, Oc M
Blood Coagul Fibrinolysis 2011 Oct;22(7):593-9. doi: 10.1097/MBC.0b013e32834a0478. PMID: 21799398
Kobayashi A, Matsuda Y, Mitani M, Makino Y, Ohta H
Clin Appl Thromb Hemost 2010 Dec;16(6):688-93. Epub 2009 Oct 14 doi: 10.1177/1076029609344085. [Epub ahead of print] PMID: 19833617

Therapy

Corder A, Held K, Oschman A
Pediatr Blood Cancer 2014 Jun;61(6):1063-7. Epub 2013 Dec 20 doi: 10.1002/pbc.24899. [Epub ahead of print] PMID: 24375987
Kim KA, Lim YY, Kim SH, Park JY
Clin Ther 2013 Nov;35(11):1752-61. Epub 2013 Oct 1 doi: 10.1016/j.clinthera.2013.08.018. [Epub ahead of print] PMID: 24094463
Perry R, Stein J, Young G, Ramanathan R, Seri I, Klee L, Friedlich P
J Pediatr Surg 2013 Sep;48(9):1837-42. doi: 10.1016/j.jpedsurg.2012.11.037. PMID: 24074654
Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Lönn J, Almroth G, Brudin L, Nayeri F
Cytokine 2012 Nov;60(2):478-86. Epub 2012 Jun 15 doi: 10.1016/j.cyto.2012.05.023. [Epub ahead of print] PMID: 22704693

Prognosis

Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Mizuguchi T, Kawamoto M, Meguro M, Son S, Nakamura Y, Harada K, Shibata T, Ota S, Hirata K
Hepatogastroenterology 2012 Mar-Apr;59(114):551-7. doi: 10.5754/hge10052. PMID: 22353523
Meng R, Li ZY, Ji X, Ding Y, Meng S, Wang X
Clin Neurol Neurosurg 2011 Jun;113(5):380-6. Epub 2011 Feb 12 doi: 10.1016/j.clineuro.2010.12.016. [Epub ahead of print] PMID: 21316837

Clinical prediction guides

Kim KA, Lim YY, Kim SH, Park JY
Clin Ther 2013 Nov;35(11):1752-61. Epub 2013 Oct 1 doi: 10.1016/j.clinthera.2013.08.018. [Epub ahead of print] PMID: 24094463
Lönn J, Almroth G, Brudin L, Nayeri F
Cytokine 2012 Nov;60(2):478-86. Epub 2012 Jun 15 doi: 10.1016/j.cyto.2012.05.023. [Epub ahead of print] PMID: 22704693
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Mizuguchi T, Kawamoto M, Meguro M, Son S, Nakamura Y, Harada K, Shibata T, Ota S, Hirata K
Hepatogastroenterology 2012 Mar-Apr;59(114):551-7. doi: 10.5754/hge10052. PMID: 22353523
Kobayashi A, Matsuda Y, Mitani M, Makino Y, Ohta H
Clin Appl Thromb Hemost 2010 Dec;16(6):688-93. Epub 2009 Oct 14 doi: 10.1177/1076029609344085. [Epub ahead of print] PMID: 19833617

Recent systematic reviews

Sidloff DA, Stather PW, Choke E, Bown MJ, Sayers RD
J Vasc Surg 2014 Feb;59(2):528-535.e4. doi: 10.1016/j.jvs.2013.10.088. PMID: 24461868
Linssen M, Mohamed M, Wevers RA, Lefeber DJ, Morava E
Mol Genet Metab 2013 May;109(1):107-11. Epub 2013 Feb 16 doi: 10.1016/j.ymgme.2013.02.006. [Epub ahead of print] PMID: 23499581
Afshari A
Dan Med Bull 2011 Sep;58(9):B4316. PMID: 21893014
Afshari A, Wetterslev J, Brok J, Møller AM
Cochrane Database Syst Rev 2008 Jul 16;(3):CD005370. doi: 10.1002/14651858.CD005370.pub2. PMID: 18646125
Afshari A, Wetterslev J, Brok J, Møller A
BMJ 2007 Dec 15;335(7632):1248-51. Epub 2007 Nov 23 doi: 10.1136/bmj.39398.682500.25. [Epub ahead of print] PMID: 18037615Free PMC Article

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