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Antithrombin III(AT3)

MedGen UID:
1993
Concept ID:
C0003438
Pharmacologic Substance
Synonyms: Cofactor I, Heparin; Heparin Co Factor I; Heparin Co-Factor I; Heparin Cofactor I; Serpin C1
SNOMED CT: Antithrombin III product (109001008); Antithrombin III preparation (109001008); Heparin cofactor I (34086003); Antithrombin II (34086003); Antithrombin III (34086003)
 
OMIM®: 107300

Definition

Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGAntithrombin III

Recent clinical studies

Etiology

Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, Shavit JA
Blood 2014 Jul 3;124(1):142-50. Epub 2014 Apr 29 doi: 10.1182/blood-2014-03-561027. [Epub ahead of print] PMID: 24782510Free PMC Article
Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9(1):73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Corder A, Held K, Oschman A
Pediatr Blood Cancer 2014 Jun;61(6):1063-7. Epub 2013 Dec 20 doi: 10.1002/pbc.24899. [Epub ahead of print] PMID: 24375987
Kumar A, Bhandari A, Sarde SJ, Goswami C
Biochem Biophys Res Commun 2013 Nov 1;440(4):714-24. Epub 2013 Oct 9 doi: 10.1016/j.bbrc.2013.09.134. [Epub ahead of print] PMID: 24121110
Perry R, Stein J, Young G, Ramanathan R, Seri I, Klee L, Friedlich P
J Pediatr Surg 2013 Sep;48(9):1837-42. doi: 10.1016/j.jpedsurg.2012.11.037. PMID: 24074654

Diagnosis

Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9(1):73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Kobayashi A, Matsuda Y, Mitani M, Makino Y, Ohta H
Clin Appl Thromb Hemost 2010 Dec;16(6):688-93. Epub 2009 Oct 14 doi: 10.1177/1076029609344085. [Epub ahead of print] PMID: 19833617

Therapy

Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9(1):73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Corder A, Held K, Oschman A
Pediatr Blood Cancer 2014 Jun;61(6):1063-7. Epub 2013 Dec 20 doi: 10.1002/pbc.24899. [Epub ahead of print] PMID: 24375987
Byrnes JW, Swearingen CJ, Prodhan P, Fiser R, Dyamenahalli U
ASAIO J 2014 Jan-Feb;60(1):57-62. doi: 10.1097/MAT.0000000000000010. PMID: 24296776
Kim KA, Lim YY, Kim SH, Park JY
Clin Ther 2013 Nov;35(11):1752-61. Epub 2013 Oct 1 doi: 10.1016/j.clinthera.2013.08.018. [Epub ahead of print] PMID: 24094463
Perry R, Stein J, Young G, Ramanathan R, Seri I, Klee L, Friedlich P
J Pediatr Surg 2013 Sep;48(9):1837-42. doi: 10.1016/j.jpedsurg.2012.11.037. PMID: 24074654

Prognosis

Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9(1):73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Mizuguchi T, Kawamoto M, Meguro M, Son S, Nakamura Y, Harada K, Shibata T, Ota S, Hirata K
Hepatogastroenterology 2012 Mar-Apr;59(114):551-7. doi: 10.5754/hge10052. PMID: 22353523

Clinical prediction guides

Byrnes JW, Swearingen CJ, Prodhan P, Fiser R, Dyamenahalli U
ASAIO J 2014 Jan-Feb;60(1):57-62. doi: 10.1097/MAT.0000000000000010. PMID: 24296776
Kim KA, Lim YY, Kim SH, Park JY
Clin Ther 2013 Nov;35(11):1752-61. Epub 2013 Oct 1 doi: 10.1016/j.clinthera.2013.08.018. [Epub ahead of print] PMID: 24094463
Lönn J, Almroth G, Brudin L, Nayeri F
Cytokine 2012 Nov;60(2):478-86. Epub 2012 Jun 15 doi: 10.1016/j.cyto.2012.05.023. [Epub ahead of print] PMID: 22704693
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Kobayashi A, Matsuda Y, Mitani M, Makino Y, Ohta H
Clin Appl Thromb Hemost 2010 Dec;16(6):688-93. Epub 2009 Oct 14 doi: 10.1177/1076029609344085. [Epub ahead of print] PMID: 19833617

Recent systematic reviews

Sidloff DA, Stather PW, Choke E, Bown MJ, Sayers RD
J Vasc Surg 2014 Feb;59(2):528-535.e4. doi: 10.1016/j.jvs.2013.10.088. PMID: 24461868
Linssen M, Mohamed M, Wevers RA, Lefeber DJ, Morava E
Mol Genet Metab 2013 May;109(1):107-11. Epub 2013 Feb 16 doi: 10.1016/j.ymgme.2013.02.006. [Epub ahead of print] PMID: 23499581
Afshari A
Dan Med Bull 2011 Sep;58(9):B4316. PMID: 21893014
Afshari A, Wetterslev J, Brok J, Møller AM
Cochrane Database Syst Rev 2008 Jul 16;(3):CD005370. doi: 10.1002/14651858.CD005370.pub2. PMID: 18646125
Afshari A, Wetterslev J, Brok J, Møller A
BMJ 2007 Dec 15;335(7632):1248-51. Epub 2007 Nov 23 doi: 10.1136/bmj.39398.682500.25. [Epub ahead of print] PMID: 18037615Free PMC Article

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