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Antithrombin III(AT3)

MedGen UID:
1993
Concept ID:
C0003438
Pharmacologic Substance
Synonyms: Cofactor I, Heparin; Heparin Co Factor I; Heparin Co-Factor I; Heparin Cofactor I; Serpin C1
SNOMED CT: Antithrombin III product (109001008); Antithrombin III preparation (109001008); Heparin cofactor I (34086003); Antithrombin II (34086003); Antithrombin III (34086003)
 
OMIM®: 107300

Definition

Antithrombin-III (464 aa, ~53 kDa) is encoded by the human SERPINC1 gene. This protein is involved in the negative regulation of serine proteinase activity during blood coagulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews
  • CROGAntithrombin III

Recent clinical studies

Etiology

Kawanaka H, Akahoshi T, Itoh S, Iguchi T, Harimoto N, Uchiyama H, Yoshizumi T, Shirabe K, Takenaka K, Maehara Y
J Am Coll Surg 2014 Nov;219(5):865-74. Epub 2014 Aug 6 doi: 10.1016/j.jamcollsurg.2014.07.939. [Epub ahead of print] PMID: 25256370
Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, Shavit JA
Blood 2014 Jul 3;124(1):142-50. Epub 2014 Apr 29 doi: 10.1182/blood-2014-03-561027. [Epub ahead of print] PMID: 24782510Free PMC Article
Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9:73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Corder A, Held K, Oschman A
Pediatr Blood Cancer 2014 Jun;61(6):1063-7. Epub 2013 Dec 20 doi: 10.1002/pbc.24899. [Epub ahead of print] PMID: 24375987
Kumar A, Bhandari A, Sarde SJ, Goswami C
Biochem Biophys Res Commun 2013 Nov 1;440(4):714-24. Epub 2013 Oct 9 doi: 10.1016/j.bbrc.2013.09.134. [Epub ahead of print] PMID: 24121110

Diagnosis

Kawanaka H, Akahoshi T, Itoh S, Iguchi T, Harimoto N, Uchiyama H, Yoshizumi T, Shirabe K, Takenaka K, Maehara Y
J Am Coll Surg 2014 Nov;219(5):865-74. Epub 2014 Aug 6 doi: 10.1016/j.jamcollsurg.2014.07.939. [Epub ahead of print] PMID: 25256370
Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9:73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667

Therapy

Kawanaka H, Akahoshi T, Itoh S, Iguchi T, Harimoto N, Uchiyama H, Yoshizumi T, Shirabe K, Takenaka K, Maehara Y
J Am Coll Surg 2014 Nov;219(5):865-74. Epub 2014 Aug 6 doi: 10.1016/j.jamcollsurg.2014.07.939. [Epub ahead of print] PMID: 25256370
Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9:73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Corder A, Held K, Oschman A
Pediatr Blood Cancer 2014 Jun;61(6):1063-7. Epub 2013 Dec 20 doi: 10.1002/pbc.24899. [Epub ahead of print] PMID: 24375987
Kim KA, Lim YY, Kim SH, Park JY
Clin Ther 2013 Nov;35(11):1752-61. Epub 2013 Oct 1 doi: 10.1016/j.clinthera.2013.08.018. [Epub ahead of print] PMID: 24094463
Perry R, Stein J, Young G, Ramanathan R, Seri I, Klee L, Friedlich P
J Pediatr Surg 2013 Sep;48(9):1837-42. doi: 10.1016/j.jpedsurg.2012.11.037. PMID: 24074654

Prognosis

Wang YQ, Chen QL, Zhu D, Dong L
J Cardiothorac Surg 2014 Apr 28;9:73. doi: 10.1186/1749-8090-9-73. [Epub ahead of print] PMID: 24775062Free PMC Article
Hattori T, Hata M, Sezai A, Wakui S, Shiono M
Ann Thorac Cardiovasc Surg 2013;19(4):323-5. Epub 2012 Nov 15 [Epub ahead of print] PMID: 23232305
Fidan E, Kavgaci H, Orem A, Yilmaz M, Yildiz B, Fidan S, Akcan B, Ozdemir F, Aydin F
Tumour Biol 2012 Oct;33(5):1519-25. Epub 2012 Apr 27 doi: 10.1007/s13277-012-0403-6. [Epub ahead of print] PMID: 22535370
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667
Mizuguchi T, Kawamoto M, Meguro M, Son S, Nakamura Y, Harada K, Shibata T, Ota S, Hirata K
Hepatogastroenterology 2012 Mar-Apr;59(114):551-7. doi: 10.5754/hge10052. PMID: 22353523

Clinical prediction guides

Quintero J, Ortega J, Miserachs M, Bueno J, Bilbao I, Charco R
Pediatr Transplant 2014 Mar;18(2):185-9. Epub 2014 Jan 20 doi: 10.1111/petr.12217. [Epub ahead of print] PMID: 24438318
Byrnes JW, Swearingen CJ, Prodhan P, Fiser R, Dyamenahalli U
ASAIO J 2014 Jan-Feb;60(1):57-62. doi: 10.1097/MAT.0000000000000010. PMID: 24296776
Kim KA, Lim YY, Kim SH, Park JY
Clin Ther 2013 Nov;35(11):1752-61. Epub 2013 Oct 1 doi: 10.1016/j.clinthera.2013.08.018. [Epub ahead of print] PMID: 24094463
Lönn J, Almroth G, Brudin L, Nayeri F
Cytokine 2012 Nov;60(2):478-86. Epub 2012 Jun 15 doi: 10.1016/j.cyto.2012.05.023. [Epub ahead of print] PMID: 22704693
Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
Ann Surg Oncol 2012 Sep;19(9):2888-96. Epub 2012 Mar 31 doi: 10.1245/s10434-012-2338-y. [Epub ahead of print] PMID: 22466667

Recent systematic reviews

Sidloff DA, Stather PW, Choke E, Bown MJ, Sayers RD
J Vasc Surg 2014 Feb;59(2):528-535.e4. doi: 10.1016/j.jvs.2013.10.088. PMID: 24461868
Linssen M, Mohamed M, Wevers RA, Lefeber DJ, Morava E
Mol Genet Metab 2013 May;109(1):107-11. Epub 2013 Feb 16 doi: 10.1016/j.ymgme.2013.02.006. [Epub ahead of print] PMID: 23499581
Afshari A
Dan Med Bull 2011 Sep;58(9):B4316. PMID: 21893014
Afshari A, Wetterslev J, Brok J, Møller AM
Cochrane Database Syst Rev 2008 Jul 16;(3):CD005370. doi: 10.1002/14651858.CD005370.pub2. PMID: 18646125
Afshari A, Wetterslev J, Brok J, Møller A
BMJ 2007 Dec 15;335(7632):1248-51. Epub 2007 Nov 23 doi: 10.1136/bmj.39398.682500.25. [Epub ahead of print] PMID: 18037615Free PMC Article

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